Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025285044> ?p ?o ?g. }
- W2025285044 endingPage "e78380" @default.
- W2025285044 startingPage "e78380" @default.
- W2025285044 abstract "Somatic cell nuclear transfer to an enucleated oocyte is used for reprogramming somatic cells with the aim of achieving totipotency, but most cloned embryos die in the uterus after transfer. While modifying epigenetic states of cloned embryos can improve their development, the production rate of cloned embryos can also be enhanced by changing other factors. It has already been shown that abnormal chromosome segregation (ACS) is a major cause of the developmental failure of cloned embryos and that Latrunculin A (LatA), an actin polymerization inhibitor, improves F-actin formation and birth rate of cloned embryos. Since F-actin is important for chromosome congression in embryos, here we examined the relation between ACS and F-actin in cloned embryos. Using LatA treatment, the occurrence of ACS decreased significantly whereas cloned embryo-specific epigenetic abnormalities such as dimethylation of histone H3 at lysine 9 (H3K9me2) could not be corrected. In contrast, when H3K9me2 was normalized using the G9a histone methyltransferase inhibitor BIX-01294, the Magea2 gene-essential for normal development but never before expressed in cloned embryos-was expressed. However, this did not increase the cloning success rate. Thus, non-epigenetic factors also play an important role in determining the efficiency of mouse cloning." @default.
- W2025285044 created "2016-06-24" @default.
- W2025285044 creator A5007912048 @default.
- W2025285044 creator A5010788480 @default.
- W2025285044 creator A5015828248 @default.
- W2025285044 creator A5018666788 @default.
- W2025285044 creator A5033838383 @default.
- W2025285044 creator A5035702067 @default.
- W2025285044 creator A5051627563 @default.
- W2025285044 creator A5053482370 @default.
- W2025285044 creator A5066432875 @default.
- W2025285044 date "2013-10-24" @default.
- W2025285044 modified "2023-09-26" @default.
- W2025285044 title "Latrunculin A Treatment Prevents Abnormal Chromosome Segregation for Successful Development of Cloned Embryos" @default.
- W2025285044 cites W1487014009 @default.
- W2025285044 cites W1497453049 @default.
- W2025285044 cites W1509466986 @default.
- W2025285044 cites W1603793127 @default.
- W2025285044 cites W1972564233 @default.
- W2025285044 cites W1974127834 @default.
- W2025285044 cites W1977050778 @default.
- W2025285044 cites W1978660434 @default.
- W2025285044 cites W1992380590 @default.
- W2025285044 cites W1992525863 @default.
- W2025285044 cites W1993767428 @default.
- W2025285044 cites W1997100349 @default.
- W2025285044 cites W1999038855 @default.
- W2025285044 cites W1999114571 @default.
- W2025285044 cites W2000091990 @default.
- W2025285044 cites W2003112871 @default.
- W2025285044 cites W2003336531 @default.
- W2025285044 cites W2006103234 @default.
- W2025285044 cites W2018051857 @default.
- W2025285044 cites W2018221132 @default.
- W2025285044 cites W2033477935 @default.
- W2025285044 cites W2045113464 @default.
- W2025285044 cites W2050608300 @default.
- W2025285044 cites W2059950394 @default.
- W2025285044 cites W2066064712 @default.
- W2025285044 cites W2070983774 @default.
- W2025285044 cites W2071953998 @default.
- W2025285044 cites W2072375728 @default.
- W2025285044 cites W2074781740 @default.
- W2025285044 cites W2093155802 @default.
- W2025285044 cites W2094115656 @default.
- W2025285044 cites W2102560467 @default.
- W2025285044 cites W2105718307 @default.
- W2025285044 cites W2113022171 @default.
- W2025285044 cites W2124207075 @default.
- W2025285044 cites W2124509928 @default.
- W2025285044 cites W2130350241 @default.
- W2025285044 cites W2133947682 @default.
- W2025285044 cites W2150374310 @default.
- W2025285044 cites W2160466009 @default.
- W2025285044 cites W2163798466 @default.
- W2025285044 cites W2166002518 @default.
- W2025285044 cites W2329061847 @default.
- W2025285044 doi "https://doi.org/10.1371/journal.pone.0078380" @default.
- W2025285044 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3813513" @default.
- W2025285044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24205216" @default.
- W2025285044 hasPublicationYear "2013" @default.
- W2025285044 type Work @default.
- W2025285044 sameAs 2025285044 @default.
- W2025285044 citedByCount "24" @default.
- W2025285044 countsByYear W20252850442014 @default.
- W2025285044 countsByYear W20252850442015 @default.
- W2025285044 countsByYear W20252850442016 @default.
- W2025285044 countsByYear W20252850442017 @default.
- W2025285044 countsByYear W20252850442018 @default.
- W2025285044 countsByYear W20252850442019 @default.
- W2025285044 countsByYear W20252850442020 @default.
- W2025285044 countsByYear W20252850442022 @default.
- W2025285044 countsByYear W20252850442023 @default.
- W2025285044 crossrefType "journal-article" @default.
- W2025285044 hasAuthorship W2025285044A5007912048 @default.
- W2025285044 hasAuthorship W2025285044A5010788480 @default.
- W2025285044 hasAuthorship W2025285044A5015828248 @default.
- W2025285044 hasAuthorship W2025285044A5018666788 @default.
- W2025285044 hasAuthorship W2025285044A5033838383 @default.
- W2025285044 hasAuthorship W2025285044A5035702067 @default.
- W2025285044 hasAuthorship W2025285044A5051627563 @default.
- W2025285044 hasAuthorship W2025285044A5053482370 @default.
- W2025285044 hasAuthorship W2025285044A5066432875 @default.
- W2025285044 hasBestOaLocation W20252850441 @default.
- W2025285044 hasConcept C104317684 @default.
- W2025285044 hasConcept C121050878 @default.
- W2025285044 hasConcept C134305767 @default.
- W2025285044 hasConcept C153911025 @default.
- W2025285044 hasConcept C196843134 @default.
- W2025285044 hasConcept C199360897 @default.
- W2025285044 hasConcept C202438428 @default.
- W2025285044 hasConcept C2776745794 @default.
- W2025285044 hasConcept C2778177303 @default.
- W2025285044 hasConcept C41008148 @default.
- W2025285044 hasConcept C41091548 @default.
- W2025285044 hasConcept C54355233 @default.
- W2025285044 hasConcept C77255625 @default.
- W2025285044 hasConcept C86803240 @default.