FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025290253> ?p ?o ?g. }

• W2025290253 endingPage "1507" @default.
• W2025290253 startingPage "1497" @default.
• W2025290253 abstract "Single-nucleotide polymorphisms (SNPs) that alter immune function, inflammatory responses, and disease susceptibility have been identified in several genes encoding Toll-like receptors (TLRs). The TLR SNPs with the best evidence of an effect on immune function are those in TLR1 (1805GG), TLR2 (2258GA), and TLR5 (1174CT). This study was undertaken to assess the frequency and functional outcomes of these polymorphisms in patients with Lyme disease.SNP frequencies and functional outcomes were assessed in 248 patients with Lyme disease. Cytokine and chemokine levels were determined using multiplex assays in the serum of patients with erythema migrans (EM), joint fluid of patients with Lyme arthritis, and supernatants of Borrelia burgdorferi-stimulated peripheral blood mononuclear cells (PBMCs) from patients with Lyme arthritis.The frequency of the TLR1-1805GG polymorphism was greater in patients with antibiotic-refractory arthritis compared with patients with EM or those with antibiotic-responsive arthritis. Early in the illness, patients with EM carrying 1805GG, primarily those infected with B burgdorferi 16S-23S ribosomal spacer RNA intergenic type 1 (RST1) strains, had higher serum levels of interferon-γ (IFNγ), CXCL9, and CXCL10 and had more severe infection than EM patients carrying the 1805TG/TT polymorphism. These inflammatory responses were amplified in patients with Lyme arthritis, and the highest responses were observed in patients with 1805GG in the antibiotic-refractory group who had been infected with RST1 strains. When PBMCs from patients with Lyme arthritis were stimulated with a B burgdorferi RST1 strain, the 1805GG group had a significantly larger fold increase in the levels of IFNγ, CCL2, CXCL9, and CXCL10 compared to the 1805TG/TT group. In contrast, the TLR2 and TLR5 polymorphisms did not vary in frequency or function among the groups.The TLR1-1805GG polymorphism in B burgdorferi RST1-infected patients was associated with stronger Th1-like inflammatory responses, an environment that may set the stage for antibiotic-refractory arthritis." @default.
• W2025290253 created "2016-06-24" @default.
• W2025290253 creator A5004628263 @default.
• W2025290253 creator A5071151203 @default.
• W2025290253 creator A5072895172 @default.
• W2025290253 creator A5081040289 @default.
• W2025290253 date "2012-04-26" @default.
• W2025290253 modified "2023-10-01" @default.
• W2025290253 title "Association of a Toll-like receptor 1 polymorphism with heightened Th1 inflammatory responses and antibiotic-refractory Lyme arthritis" @default.
• W2025290253 cites W1905843327 @default.
• W2025290253 cites W1922236261 @default.
• W2025290253 cites W1926303070 @default.
• W2025290253 cites W1966935901 @default.
• W2025290253 cites W1970955576 @default.
• W2025290253 cites W1972421342 @default.
• W2025290253 cites W1975608178 @default.
• W2025290253 cites W2000697080 @default.
• W2025290253 cites W2006426063 @default.
• W2025290253 cites W2016216159 @default.
• W2025290253 cites W2019431037 @default.
• W2025290253 cites W2023996015 @default.
• W2025290253 cites W2025202479 @default.
• W2025290253 cites W2025609755 @default.
• W2025290253 cites W2038444567 @default.
• W2025290253 cites W2050294315 @default.
• W2025290253 cites W2052621996 @default.
• W2025290253 cites W2057835577 @default.
• W2025290253 cites W2078342014 @default.
• W2025290253 cites W2079955793 @default.
• W2025290253 cites W2081996287 @default.
• W2025290253 cites W2086278698 @default.
• W2025290253 cites W2089050791 @default.
• W2025290253 cites W2091229884 @default.
• W2025290253 cites W2096743939 @default.
• W2025290253 cites W2103089222 @default.
• W2025290253 cites W2104211946 @default.
• W2025290253 cites W2104334002 @default.
• W2025290253 cites W2105281406 @default.
• W2025290253 cites W2107621690 @default.
• W2025290253 cites W2107674270 @default.
• W2025290253 cites W2107762058 @default.
• W2025290253 cites W2110042372 @default.
• W2025290253 cites W2113561897 @default.
• W2025290253 cites W2133866452 @default.
• W2025290253 cites W2145981344 @default.
• W2025290253 cites W2147636984 @default.
• W2025290253 cites W2151438883 @default.
• W2025290253 cites W2156255552 @default.
• W2025290253 cites W2157319757 @default.
• W2025290253 cites W2159432050 @default.
• W2025290253 cites W2160012920 @default.
• W2025290253 cites W2168836215 @default.
• W2025290253 cites W2171323358 @default.
• W2025290253 cites W4239494812 @default.
• W2025290253 cites W4239983740 @default.
• W2025290253 doi "https://doi.org/10.1002/art.34383" @default.
• W2025290253 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3338893" @default.
• W2025290253 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22246581" @default.
• W2025290253 hasPublicationYear "2012" @default.
• W2025290253 type Work @default.
• W2025290253 sameAs 2025290253 @default.
• W2025290253 citedByCount "118" @default.
• W2025290253 countsByYear W20252902532012 @default.
• W2025290253 countsByYear W20252902532013 @default.
• W2025290253 countsByYear W20252902532014 @default.
• W2025290253 countsByYear W20252902532015 @default.
• W2025290253 countsByYear W20252902532016 @default.
• W2025290253 countsByYear W20252902532017 @default.
• W2025290253 countsByYear W20252902532018 @default.
• W2025290253 countsByYear W20252902532019 @default.
• W2025290253 countsByYear W20252902532020 @default.
• W2025290253 countsByYear W20252902532021 @default.
• W2025290253 countsByYear W20252902532022 @default.
• W2025290253 countsByYear W20252902532023 @default.
• W2025290253 crossrefType "journal-article" @default.
• W2025290253 hasAuthorship W2025290253A5004628263 @default.
• W2025290253 hasAuthorship W2025290253A5071151203 @default.
• W2025290253 hasAuthorship W2025290253A5072895172 @default.
• W2025290253 hasAuthorship W2025290253A5081040289 @default.
• W2025290253 hasBestOaLocation W20252902532 @default.
• W2025290253 hasConcept C104317684 @default.
• W2025290253 hasConcept C135763542 @default.
• W2025290253 hasConcept C136449434 @default.
• W2025290253 hasConcept C153209595 @default.
• W2025290253 hasConcept C203014093 @default.
• W2025290253 hasConcept C2776709828 @default.
• W2025290253 hasConcept C2776821229 @default.
• W2025290253 hasConcept C2777077863 @default.
• W2025290253 hasConcept C2777338127 @default.
• W2025290253 hasConcept C2777553296 @default.
• W2025290253 hasConcept C54355233 @default.
• W2025290253 hasConcept C71924100 @default.
• W2025290253 hasConcept C86803240 @default.
• W2025290253 hasConcept C8891405 @default.
• W2025290253 hasConceptScore W2025290253C104317684 @default.
• W2025290253 hasConceptScore W2025290253C135763542 @default.
• W2025290253 hasConceptScore W2025290253C136449434 @default.
• W2025290253 hasConceptScore W2025290253C153209595 @default.

• next