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- W2025292518 endingPage "581" @default.
- W2025292518 startingPage "569" @default.
- W2025292518 abstract "Humans are routinely exposed to a vast array of environmental neurotoxicants, including pesticides, endocrine disrupters, and heavy metals. The long-term consequences of exposure have become a major human health concern as research has indicated strong associations between neurotoxicants and a variety of dopamine-related neurological disorders. Developmental exposure to pesticides including paraquat, organochlorines, and rotenone produce alterations in the dopaminergic system and has been linked to neurodegenerative disorders, including Parkinson's disease. Endocrine disrupters such as Bisphenol A, mimic estrogenic activity and impact various dopaminergic processes to enhance mesolimbic dopamine activity resulting in hyperactivity, attention deficits, and a heightened sensitivity to drugs of abuse. A second class of endocrine disrupters, the polychlorinated biphenyls, may act directly on dopaminergic processes to disrupt the dopamine system and produce Parkinson-like symptoms. Exposure to the heavy metal lead enhances dopaminergic activity and has been associated with attention deficits, Alzheimer's disease, and increased drug sensitivity. Manganese exposure, in contrast, results in dopamine deficiencies and Parkinson-like symptoms. Therefore, this commentary will discuss the effects and consequences that exposure to these three classes of environmental neurotoxicants have on the dopamine system and related behaviors and disorders. Finally, the recent hypothesis that exposure to environmental compounds which have effects on dopaminergic neurotransmission, including 2,4-dichlorophenoxyacetic acid, Bisphenol A, and multiple heavy metals, may potentiate drug-induced behaviors and increase the brain's vulnerability to drug addiction will be discussed." @default.
- W2025292518 created "2016-06-24" @default.
- W2025292518 creator A5018110335 @default.
- W2025292518 creator A5069002204 @default.
- W2025292518 date "2008-09-01" @default.
- W2025292518 modified "2023-10-02" @default.
- W2025292518 title "The effects of environmental neurotoxicants on the dopaminergic system: A possible role in drug addiction" @default.
- W2025292518 cites W1521920128 @default.
- W2025292518 cites W1560454004 @default.
- W2025292518 cites W1577439606 @default.
- W2025292518 cites W1595909085 @default.
- W2025292518 cites W1645031292 @default.
- W2025292518 cites W1677564607 @default.
- W2025292518 cites W1902946357 @default.
- W2025292518 cites W1954514489 @default.
- W2025292518 cites W1963562655 @default.
- W2025292518 cites W1969195984 @default.
- W2025292518 cites W1972912204 @default.
- W2025292518 cites W1973388967 @default.
- W2025292518 cites W1974212152 @default.
- W2025292518 cites W1987722108 @default.
- W2025292518 cites W1990299071 @default.
- W2025292518 cites W1992019774 @default.
- W2025292518 cites W1992241432 @default.
- W2025292518 cites W1994017570 @default.
- W2025292518 cites W1996906166 @default.
- W2025292518 cites W2003626747 @default.
- W2025292518 cites W2006642289 @default.
- W2025292518 cites W2007530757 @default.
- W2025292518 cites W2008767311 @default.
- W2025292518 cites W2008799105 @default.
- W2025292518 cites W2010277507 @default.
- W2025292518 cites W2010312082 @default.
- W2025292518 cites W2013819259 @default.
- W2025292518 cites W2015527159 @default.
- W2025292518 cites W2020974826 @default.
- W2025292518 cites W2022871657 @default.
- W2025292518 cites W2023073183 @default.
- W2025292518 cites W2023484584 @default.
- W2025292518 cites W2023590101 @default.
- W2025292518 cites W2024219755 @default.
- W2025292518 cites W2024780119 @default.
- W2025292518 cites W2027220030 @default.
- W2025292518 cites W2031158487 @default.
- W2025292518 cites W2035111849 @default.
- W2025292518 cites W2035648212 @default.
- W2025292518 cites W2035817290 @default.
- W2025292518 cites W2037977556 @default.
- W2025292518 cites W2038071695 @default.
- W2025292518 cites W2042240432 @default.
- W2025292518 cites W2044091094 @default.
- W2025292518 cites W2044295177 @default.
- W2025292518 cites W2045394310 @default.
- W2025292518 cites W2048787663 @default.
- W2025292518 cites W2049088192 @default.
- W2025292518 cites W2049109427 @default.
- W2025292518 cites W2054064910 @default.
- W2025292518 cites W2054351060 @default.
- W2025292518 cites W2055097003 @default.
- W2025292518 cites W2057001027 @default.
- W2025292518 cites W2058547996 @default.
- W2025292518 cites W2059595475 @default.
- W2025292518 cites W2061175278 @default.
- W2025292518 cites W2061687910 @default.
- W2025292518 cites W2062605045 @default.
- W2025292518 cites W2065462657 @default.
- W2025292518 cites W2065912251 @default.
- W2025292518 cites W2066452883 @default.
- W2025292518 cites W2067205443 @default.
- W2025292518 cites W2067545369 @default.
- W2025292518 cites W2071316590 @default.
- W2025292518 cites W2071786082 @default.
- W2025292518 cites W2072009968 @default.
- W2025292518 cites W2072589021 @default.
- W2025292518 cites W2072955000 @default.
- W2025292518 cites W2073668281 @default.
- W2025292518 cites W2074833985 @default.
- W2025292518 cites W2075241114 @default.
- W2025292518 cites W2081714605 @default.
- W2025292518 cites W2086541750 @default.
- W2025292518 cites W2088910177 @default.
- W2025292518 cites W2089207822 @default.
- W2025292518 cites W2091850152 @default.
- W2025292518 cites W2091955701 @default.
- W2025292518 cites W2101802267 @default.
- W2025292518 cites W2104333700 @default.
- W2025292518 cites W2114355876 @default.
- W2025292518 cites W2114857126 @default.
- W2025292518 cites W2116504386 @default.
- W2025292518 cites W2118207252 @default.
- W2025292518 cites W2120887338 @default.
- W2025292518 cites W2121080336 @default.
- W2025292518 cites W2123714584 @default.
- W2025292518 cites W2127188314 @default.
- W2025292518 cites W2138923443 @default.
- W2025292518 cites W2140513029 @default.
- W2025292518 cites W2144096895 @default.
- W2025292518 cites W2152390280 @default.