FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025301971> ?p ?o ?g. }

• W2025301971 endingPage "200" @default.
• W2025301971 startingPage "191" @default.
• W2025301971 abstract "<i>Objectives:</i> Molecular studies for genetic polymorphisms are being carried out for a number of different applications, such as genetic disorders in different populations, pharmacogenomics, genetic identification of ethnic groups for forensic and legal applications, genetic identification of breed/stock in animals and plants for commercial applications and conservation of germ plasm. In this paper, for a random sampling scheme, we address two questions: (A) What should be the minimum size of the sample so that, with a prespecified probability, all alleles at a given locus (or haplotypes at a given set of loci) are detected? (B) What should be the sample size so that the allele frequency distribution at a given locus (or haplotype frequency distribution at a given set of loci) is estimated reliably within permissible error limits? <i>Methods:</i> We have used combinatorial probabilistic arguments and Monte Carlo simulations to answer these questions. <i>Results:</i> We found that the minimum sample size required in case A depends mainly on the prespecified probability of detecting all alleles, while in case B, it varies greatly depending on the permissible error in estimation (which will vary with the application). We have obtained the minimum sample sizes for different degrees of polymorphism at a locus under high stringency, as well as a relaxed level of permissible error. We present a detailed sampling procedure for estimating allele frequencies at a given locus, which will be of use in practical applications. <i>Conclusion:</i> Since the sample size required for reliable estimation of allele frequency distribution increases with the number of alleles at the locus, there is a strong case for using biallelic markers (like single nucleotide polymorphisms) when the available sample size is about 800 or less." @default.
• W2025301971 created "2016-06-24" @default.
• W2025301971 creator A5090261958 @default.
• W2025301971 date "2001-01-01" @default.
• W2025301971 modified "2023-09-30" @default.
• W2025301971 title "Sample Size Considerations in Genetic Polymorphism Studies" @default.
• W2025301971 cites W1978910518 @default.
• W2025301971 cites W2066856556 @default.
• W2025301971 cites W2082962246 @default.
• W2025301971 cites W2120501716 @default.
• W2025301971 cites W2154920982 @default.
• W2025301971 cites W2283148381 @default.
• W2025301971 cites W3201211840 @default.
• W2025301971 doi "https://doi.org/10.1159/000053376" @default.
• W2025301971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11713415" @default.
• W2025301971 hasPublicationYear "2001" @default.
• W2025301971 type Work @default.
• W2025301971 sameAs 2025301971 @default.
• W2025301971 citedByCount "30" @default.
• W2025301971 countsByYear W20253019712012 @default.
• W2025301971 countsByYear W20253019712013 @default.
• W2025301971 countsByYear W20253019712014 @default.
• W2025301971 countsByYear W20253019712015 @default.
• W2025301971 countsByYear W20253019712016 @default.
• W2025301971 countsByYear W20253019712017 @default.
• W2025301971 countsByYear W20253019712018 @default.
• W2025301971 countsByYear W20253019712021 @default.
• W2025301971 countsByYear W20253019712022 @default.
• W2025301971 countsByYear W20253019712023 @default.
• W2025301971 crossrefType "journal-article" @default.
• W2025301971 hasAuthorship W2025301971A5090261958 @default.
• W2025301971 hasConcept C104317684 @default.
• W2025301971 hasConcept C105795698 @default.
• W2025301971 hasConcept C129848803 @default.
• W2025301971 hasConcept C180754005 @default.
• W2025301971 hasConcept C197754878 @default.
• W2025301971 hasConcept C33923547 @default.
• W2025301971 hasConcept C37463918 @default.
• W2025301971 hasConcept C54355233 @default.
• W2025301971 hasConcept C84597430 @default.
• W2025301971 hasConcept C86803240 @default.
• W2025301971 hasConceptScore W2025301971C104317684 @default.
• W2025301971 hasConceptScore W2025301971C105795698 @default.
• W2025301971 hasConceptScore W2025301971C129848803 @default.
• W2025301971 hasConceptScore W2025301971C180754005 @default.
• W2025301971 hasConceptScore W2025301971C197754878 @default.
• W2025301971 hasConceptScore W2025301971C33923547 @default.
• W2025301971 hasConceptScore W2025301971C37463918 @default.
• W2025301971 hasConceptScore W2025301971C54355233 @default.
• W2025301971 hasConceptScore W2025301971C84597430 @default.
• W2025301971 hasConceptScore W2025301971C86803240 @default.
• W2025301971 hasIssue "4" @default.
• W2025301971 hasLocation W20253019711 @default.
• W2025301971 hasLocation W20253019712 @default.
• W2025301971 hasOpenAccess W2025301971 @default.
• W2025301971 hasPrimaryLocation W20253019711 @default.
• W2025301971 hasRelatedWork W1551477413 @default.
• W2025301971 hasRelatedWork W1982749768 @default.
• W2025301971 hasRelatedWork W2011656750 @default.
• W2025301971 hasRelatedWork W2057739827 @default.
• W2025301971 hasRelatedWork W2071887209 @default.
• W2025301971 hasRelatedWork W2087118228 @default.
• W2025301971 hasRelatedWork W2105639028 @default.
• W2025301971 hasRelatedWork W2117951408 @default.
• W2025301971 hasRelatedWork W2155294402 @default.
• W2025301971 hasRelatedWork W4234789023 @default.
• W2025301971 hasVolume "52" @default.
• W2025301971 isParatext "false" @default.
• W2025301971 isRetracted "false" @default.
• W2025301971 magId "2025301971" @default.
• W2025301971 workType "article" @default.