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- W2025313988 abstract "Autoimmune inflammation secondary to myelin destruction may play an inhibitory role in restoration of nerve functions in spinal cord injury (SCI). In this study, we demonstrated that T cells recognizing myelin basic protein (MBP) occurred at a high precursor frequency in patients with SCI, which was compatible to that in patients with multiple sclerosis (MS), a disease of presumed autoimmune pathology. The findings suggest of hyperactivity of MBP-reactive T cells in patients with SCI. MBP-reactive T cell lines derived from patients with SCI exhibited a preferential recognition pattern toward the 81–99 and the 151–169 regions of MBP. There were functional differences in the epitope recognition and cytokine profile between two panels of MBP-reactive T cell lines derived from patients with SCI and patients with MS. The study provides new evidence important for further investigation of the role of the inflammatory component in SCI." @default.
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- W2025313988 date "1999-08-01" @default.
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- W2025313988 title "T cell responses to myelin basic protein in patients with spinal cord injury and multiple sclerosis" @default.
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- W2025313988 doi "https://doi.org/10.1016/s0165-5728(99)00057-0" @default.
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