Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025326121> ?p ?o ?g. }
- W2025326121 endingPage "894" @default.
- W2025326121 startingPage "884" @default.
- W2025326121 abstract "Diet, exercise, stress, and sleep are receiving attention as environmental modifiers of chronic inflammatory diseases, including atherosclerosis, the culprit condition of myocardial infarction and stroke. Accumulating data indicate that psychosocial stress and a high-fat, high-cholesterol diet aggravate cardiovascular disease, whereas regular physical activity and healthy sleeping habits help prevent it. Here, we raise the possibility that inflammation-associated leukocyte production plays a causal role in lifestyle effects on atherosclerosis progression. Specifically, we explore whether and how potent real-life disease modifiers influence hematopoiesis’ molecular and cellular machinery. Lifestyle, we hypothesize, may rearrange hematopoietic topography, diverting production from the bone marrow to the periphery, thus propagating a quantitative and qualitative drift of the macrophage supply chain. These changes may involve progenitor-extrinsic and intrinsic communication nodes that connect organ systems along neuroimmune and immunometabolic axes, ultimately leading to an altered number and phenotype of lesional macrophages. We propose that, in conjunction with improved public health policy, future therapeutics could aim to modulate the quantitative and qualitative output, as well as the location, of the hematopoietic tree to decrease the risk of atherosclerosis complications." @default.
- W2025326121 created "2016-06-24" @default.
- W2025326121 creator A5034311334 @default.
- W2025326121 creator A5078805078 @default.
- W2025326121 date "2015-02-27" @default.
- W2025326121 modified "2023-10-03" @default.
- W2025326121 title "Lifestyle Effects on Hematopoiesis and Atherosclerosis" @default.
- W2025326121 cites W1211632029 @default.
- W2025326121 cites W1516434930 @default.
- W2025326121 cites W1520207918 @default.
- W2025326121 cites W18925082 @default.
- W2025326121 cites W1901457319 @default.
- W2025326121 cites W196017395 @default.
- W2025326121 cites W1964044304 @default.
- W2025326121 cites W1964369726 @default.
- W2025326121 cites W1971003548 @default.
- W2025326121 cites W1975296142 @default.
- W2025326121 cites W1977202406 @default.
- W2025326121 cites W1977325333 @default.
- W2025326121 cites W1984996259 @default.
- W2025326121 cites W1987538872 @default.
- W2025326121 cites W1987576415 @default.
- W2025326121 cites W1992958840 @default.
- W2025326121 cites W1994174603 @default.
- W2025326121 cites W1994343513 @default.
- W2025326121 cites W1995299599 @default.
- W2025326121 cites W1997274278 @default.
- W2025326121 cites W1997447547 @default.
- W2025326121 cites W1998234914 @default.
- W2025326121 cites W2001334954 @default.
- W2025326121 cites W2002041877 @default.
- W2025326121 cites W2002072152 @default.
- W2025326121 cites W2002514645 @default.
- W2025326121 cites W2007143131 @default.
- W2025326121 cites W2008632611 @default.
- W2025326121 cites W2008869160 @default.
- W2025326121 cites W2011363498 @default.
- W2025326121 cites W2012663953 @default.
- W2025326121 cites W2016186842 @default.
- W2025326121 cites W2021056005 @default.
- W2025326121 cites W2022485121 @default.
- W2025326121 cites W2030891480 @default.
- W2025326121 cites W2031047943 @default.
- W2025326121 cites W2034713111 @default.
- W2025326121 cites W2037427175 @default.
- W2025326121 cites W2040153748 @default.
- W2025326121 cites W2045222138 @default.
- W2025326121 cites W2048469790 @default.
- W2025326121 cites W2048811924 @default.
- W2025326121 cites W2050782363 @default.
- W2025326121 cites W2050965690 @default.
- W2025326121 cites W2052554962 @default.
- W2025326121 cites W2052730253 @default.
- W2025326121 cites W2053234401 @default.
- W2025326121 cites W2054540776 @default.
- W2025326121 cites W2055620105 @default.
- W2025326121 cites W2062230565 @default.
- W2025326121 cites W2064414835 @default.
- W2025326121 cites W2066654800 @default.
- W2025326121 cites W2066963386 @default.
- W2025326121 cites W2068714945 @default.
- W2025326121 cites W2069943416 @default.
- W2025326121 cites W2076633494 @default.
- W2025326121 cites W2077604647 @default.
- W2025326121 cites W2078599166 @default.
- W2025326121 cites W2079724669 @default.
- W2025326121 cites W2083875480 @default.
- W2025326121 cites W2084104194 @default.
- W2025326121 cites W2084628164 @default.
- W2025326121 cites W2085814883 @default.
- W2025326121 cites W2086243699 @default.
- W2025326121 cites W2090209293 @default.
- W2025326121 cites W2090689798 @default.
- W2025326121 cites W2091875614 @default.
- W2025326121 cites W2094482876 @default.
- W2025326121 cites W2094914236 @default.
- W2025326121 cites W2099172760 @default.
- W2025326121 cites W2100820895 @default.
- W2025326121 cites W2102110229 @default.
- W2025326121 cites W2106427090 @default.
- W2025326121 cites W2108038374 @default.
- W2025326121 cites W2108737237 @default.
- W2025326121 cites W2110522622 @default.
- W2025326121 cites W2112098540 @default.
- W2025326121 cites W2113934014 @default.
- W2025326121 cites W2114542748 @default.
- W2025326121 cites W2115620963 @default.
- W2025326121 cites W2117764631 @default.
- W2025326121 cites W2117893382 @default.
- W2025326121 cites W2119610102 @default.
- W2025326121 cites W2119692628 @default.
- W2025326121 cites W2121517562 @default.
- W2025326121 cites W2121524723 @default.
- W2025326121 cites W2126625630 @default.
- W2025326121 cites W2126811287 @default.
- W2025326121 cites W2128153673 @default.
- W2025326121 cites W2129663763 @default.
- W2025326121 cites W2137114549 @default.