Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025328343> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2025328343 endingPage "551" @default.
- W2025328343 startingPage "539" @default.
- W2025328343 abstract "We have evaluated the biosynthesis, characterization and inhibition of Leukotriene (LT) B4 in unstimulated and in A23187-stimulated human whole blood. LTB4 was assayed by radioimmunoassay (RIA) both in unextracted serum and after extraction and thin-layer chromatography (TLC). Unstimulated human whole blood allowed to clot at 37 degrees C for 60 min produced only trace amounts of LTB4 (0.16 +/- 0.05 ng/ml, mean +/- SD, n = 3). LTB4-like immunoreactivity (ir-LTB4) detectable in unstimulated serum samples was largely overestimated by direct RIA, most likely because of interfering substance(s) unrelated to cyclooxygenase or lipoxygenase activity. Incubation of human whole blood with A23187 (2-10 microM) resulted in a concentration-dependent stimulation of LTB4 production. At 10 microM A23187, ir-LTB4 was 18 +/- 2.4 ng/ml (mean +/- SEM, n = 28). In A23187-stimulated serum samples, LTB4 concentrations measured by direct RIA correlated in a statistically significant fashion with those measured after extraction and TLC. Nafazatrom added in vitro caused a dose-dependent inhibition of A23187-stimulated ir-LTB4 production with an IC50 of 17 microM." @default.
- W2025328343 created "2016-06-24" @default.
- W2025328343 creator A5017030833 @default.
- W2025328343 creator A5071758568 @default.
- W2025328343 date "1987-04-01" @default.
- W2025328343 modified "2023-09-26" @default.
- W2025328343 title "Biosynthesis, characterization and inhibition of leukotriene B4 in human whole blood" @default.
- W2025328343 cites W1483781996 @default.
- W2025328343 cites W1489272732 @default.
- W2025328343 cites W1515427160 @default.
- W2025328343 cites W1542903753 @default.
- W2025328343 cites W1631595783 @default.
- W2025328343 cites W1992220924 @default.
- W2025328343 cites W2011861566 @default.
- W2025328343 cites W2013457634 @default.
- W2025328343 cites W2015850083 @default.
- W2025328343 cites W2017774147 @default.
- W2025328343 cites W2036797638 @default.
- W2025328343 cites W2048950393 @default.
- W2025328343 cites W2065234246 @default.
- W2025328343 cites W2076658850 @default.
- W2025328343 cites W2087571859 @default.
- W2025328343 doi "https://doi.org/10.1016/0090-6980(87)90277-2" @default.
- W2025328343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3037608" @default.
- W2025328343 hasPublicationYear "1987" @default.
- W2025328343 type Work @default.
- W2025328343 sameAs 2025328343 @default.
- W2025328343 citedByCount "21" @default.
- W2025328343 crossrefType "journal-article" @default.
- W2025328343 hasAuthorship W2025328343A5017030833 @default.
- W2025328343 hasAuthorship W2025328343A5071758568 @default.
- W2025328343 hasConcept C126322002 @default.
- W2025328343 hasConcept C134018914 @default.
- W2025328343 hasConcept C1621761 @default.
- W2025328343 hasConcept C176685330 @default.
- W2025328343 hasConcept C181199279 @default.
- W2025328343 hasConcept C185592680 @default.
- W2025328343 hasConcept C202751555 @default.
- W2025328343 hasConcept C24998067 @default.
- W2025328343 hasConcept C25642318 @default.
- W2025328343 hasConcept C2776042228 @default.
- W2025328343 hasConcept C2776452501 @default.
- W2025328343 hasConcept C2776685179 @default.
- W2025328343 hasConcept C2776914184 @default.
- W2025328343 hasConcept C2780857362 @default.
- W2025328343 hasConcept C43617362 @default.
- W2025328343 hasConcept C55493867 @default.
- W2025328343 hasConcept C71924100 @default.
- W2025328343 hasConcept C86803240 @default.
- W2025328343 hasConceptScore W2025328343C126322002 @default.
- W2025328343 hasConceptScore W2025328343C134018914 @default.
- W2025328343 hasConceptScore W2025328343C1621761 @default.
- W2025328343 hasConceptScore W2025328343C176685330 @default.
- W2025328343 hasConceptScore W2025328343C181199279 @default.
- W2025328343 hasConceptScore W2025328343C185592680 @default.
- W2025328343 hasConceptScore W2025328343C202751555 @default.
- W2025328343 hasConceptScore W2025328343C24998067 @default.
- W2025328343 hasConceptScore W2025328343C25642318 @default.
- W2025328343 hasConceptScore W2025328343C2776042228 @default.
- W2025328343 hasConceptScore W2025328343C2776452501 @default.
- W2025328343 hasConceptScore W2025328343C2776685179 @default.
- W2025328343 hasConceptScore W2025328343C2776914184 @default.
- W2025328343 hasConceptScore W2025328343C2780857362 @default.
- W2025328343 hasConceptScore W2025328343C43617362 @default.
- W2025328343 hasConceptScore W2025328343C55493867 @default.
- W2025328343 hasConceptScore W2025328343C71924100 @default.
- W2025328343 hasConceptScore W2025328343C86803240 @default.
- W2025328343 hasIssue "4" @default.
- W2025328343 hasLocation W20253283431 @default.
- W2025328343 hasLocation W20253283432 @default.
- W2025328343 hasOpenAccess W2025328343 @default.
- W2025328343 hasPrimaryLocation W20253283431 @default.
- W2025328343 hasRelatedWork W1966646555 @default.
- W2025328343 hasRelatedWork W1999008157 @default.
- W2025328343 hasRelatedWork W2015074581 @default.
- W2025328343 hasRelatedWork W2020234330 @default.
- W2025328343 hasRelatedWork W2025328343 @default.
- W2025328343 hasRelatedWork W2042523399 @default.
- W2025328343 hasRelatedWork W2044896616 @default.
- W2025328343 hasRelatedWork W2064941106 @default.
- W2025328343 hasRelatedWork W2393145372 @default.
- W2025328343 hasRelatedWork W2433958089 @default.
- W2025328343 hasVolume "33" @default.
- W2025328343 isParatext "false" @default.
- W2025328343 isRetracted "false" @default.
- W2025328343 magId "2025328343" @default.
- W2025328343 workType "article" @default.