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• W2025331652 endingPage "2746" @default.
• W2025331652 startingPage "2737" @default.
• W2025331652 abstract "The cellular properties of long-term potentiation (LTP) following pairing of pre- and postsynaptic activity were examined at a known glutamatergic synapse in the leech, specifically between the pressure (P) mechanosensory and anterior pagoda (AP) neurons. Stimulation of the presynaptic P cell (25 Hz) concurrent with a 2 nA depolarization of the postsynaptic AP cell significantly potentiated the P-to-AP excitatory postsynaptic potential (EPSP) in an N-methyl-d-aspartate receptor (NMDAR)-dependent manner based on inhibitory effects of the NMDAR antagonist MK801 and inhibition of the NMDAR glycine binding site by 7-chlorokynurenic acid. LTP was blocked by injection of bis-( o-aminophenoxy)- N,N,N′,N′-tetraacetic acid (BAPTA) into the postsynaptic (AP) cell, indicating a requirement for postsynaptic elevation of intracellular Ca 2+ . Autocamtide-2-related inhibitory peptide (AIP), a specific inhibitor of Ca 2+ /calmodulin-dependent kinase II (CaMKII), and Rp-cAMP, an inhibitor of protein kinase A (PKA), also blocked pairing-induced potentiation, indicating a requirement for activation of CaMKII and PKA. Interestingly, application of AIP during pairing resulted in significantly depressed synaptic transmission. Co-application of AIP with the protein phosphatase inhibitor okadaic acid restored synaptic transmission to baseline levels, suggesting an interaction between CaMKII and protein phosphatases during induction of activity-dependent synaptic plasticity. When postsynaptic activity preceded presynaptic activity, NMDAR-dependent long-term depression (LTD) was observed that was blocked by okadaic acid. Postsynaptic injection of botulinum toxin blocked P-to-AP potentiation while postsynaptic injection of pep2-SVKI, an inhibitor of AMPA receptor endocytosis, inhibited LTD, supporting the hypothesis that glutamate receptor trafficking contributes to both LTP and LTD at the P-to-AP synapse in the leech." @default.
• W2025331652 created "2016-06-24" @default.
• W2025331652 creator A5059454033 @default.
• W2025331652 creator A5091260987 @default.
• W2025331652 date "2010-05-01" @default.
• W2025331652 modified "2023-09-24" @default.
• W2025331652 title "Co-Induction of LTP and LTD and Its Regulation by Protein Kinases and Phosphatases" @default.
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• W2025331652 doi "https://doi.org/10.1152/jn.01112.2009" @default.
• W2025331652 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2867558" @default.
• W2025331652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20457859" @default.
• W2025331652 hasPublicationYear "2010" @default.
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