FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025333501> ?p ?o ?g. }

• W2025333501 endingPage "338" @default.
• W2025333501 startingPage "332" @default.
• W2025333501 abstract "Although sulfonylurea added to metformin is the first oral drug combination regimen for patients with type 2 diabetes recommended by the American Diabetes Association/European Association for the Study of Diabetes consensus statement, it does not allow for individualizing and optimizing therapy with respect to sustaining glycemic control and the reduction of glucose variability. We therefore sought to investigate acarbose as an alternative to glibenclamide in combination with metformin and compare the effects on metabolic control and glucose variability.Type 2 diabetic patients 30-70 years of age with glycosylated hemoglobin 7.0%-11.0% while treated with one or two oral antidiabetic drugs were successively enrolled. After 8 weeks of run-in with metformin 500 mg thrice daily, either acarbose 50 mg or glibenclamide 2.5 mg three times daily was randomly added on and force titrated to acarbose 100 mg or glibenclamide 5.0 mg three times daily for the subsequent 16 weeks. Demographic data, biochemical data and continuous glucose monitoring system data were recorded upon randomization and at the end of the study. Various parameters that measure glucose variability were derived from the continuous glucose monitoring system data.Of the 51 type 2 diabetes patients enrolled, data from 40 subjects, 20 in each group, were analyzed after excluding those unqualified information. Both drug combinations improved glycemic control. Glucose variability, expressed as mean amplitude of glycemic excursion or continuous overall net glycemic action and mean of daily differences, decreased significantly (all P<.05) after the addition of acarbose but not glibenclamide. The acarbose-metformin combination has the additional benefits of weight reduction and shorter durations of hyperglycemia compared with metformin monotherapy.This study suggests that both intraday and interday glucose variability are more effectively reduced by the acarbose-metformin combination than by the glibenclamide-metformin combination, while both combinations reduce the overall glucose level equally." @default.
• W2025333501 created "2016-06-24" @default.
• W2025333501 creator A5019616762 @default.
• W2025333501 creator A5023194621 @default.
• W2025333501 creator A5027812322 @default.
• W2025333501 creator A5043619702 @default.
• W2025333501 creator A5045591505 @default.
• W2025333501 creator A5061870691 @default.
• W2025333501 creator A5064710593 @default.
• W2025333501 creator A5066189734 @default.
• W2025333501 creator A5069264476 @default.
• W2025333501 creator A5074833626 @default.
• W2025333501 date "2011-09-01" @default.
• W2025333501 modified "2023-09-27" @default.
• W2025333501 title "The beneficial effect of α-glucosidase inhibitor on glucose variability compared with sulfonylurea in Taiwanese type 2 diabetic patients inadequately controlled with metformin: preliminary data" @default.
• W2025333501 cites W145990486 @default.
• W2025333501 cites W1855278889 @default.
• W2025333501 cites W1930639259 @default.
• W2025333501 cites W1967265218 @default.
• W2025333501 cites W1973216483 @default.
• W2025333501 cites W1991671068 @default.
• W2025333501 cites W2002078774 @default.
• W2025333501 cites W2007578342 @default.
• W2025333501 cites W2017421207 @default.
• W2025333501 cites W2024412869 @default.
• W2025333501 cites W2029749250 @default.
• W2025333501 cites W2031916024 @default.
• W2025333501 cites W2032912656 @default.
• W2025333501 cites W2041664630 @default.
• W2025333501 cites W2045596475 @default.
• W2025333501 cites W2046262211 @default.
• W2025333501 cites W2050100411 @default.
• W2025333501 cites W2069150029 @default.
• W2025333501 cites W2073068020 @default.
• W2025333501 cites W2083342497 @default.
• W2025333501 cites W2095784604 @default.
• W2025333501 cites W2096194519 @default.
• W2025333501 cites W2107596227 @default.
• W2025333501 cites W2110465067 @default.
• W2025333501 cites W2111485734 @default.
• W2025333501 cites W2119217129 @default.
• W2025333501 cites W2120704605 @default.
• W2025333501 cites W2139562487 @default.
• W2025333501 cites W2144384987 @default.
• W2025333501 cites W2145562665 @default.
• W2025333501 cites W2146195711 @default.
• W2025333501 cites W2153449155 @default.
• W2025333501 cites W2163397777 @default.
• W2025333501 cites W2166935017 @default.
• W2025333501 doi "https://doi.org/10.1016/j.jdiacomp.2011.06.004" @default.
• W2025333501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21813293" @default.
• W2025333501 hasPublicationYear "2011" @default.
• W2025333501 type Work @default.
• W2025333501 sameAs 2025333501 @default.
• W2025333501 citedByCount "31" @default.
• W2025333501 countsByYear W20253335012012 @default.
• W2025333501 countsByYear W20253335012013 @default.
• W2025333501 countsByYear W20253335012014 @default.
• W2025333501 countsByYear W20253335012015 @default.
• W2025333501 countsByYear W20253335012016 @default.
• W2025333501 countsByYear W20253335012017 @default.
• W2025333501 countsByYear W20253335012018 @default.
• W2025333501 countsByYear W20253335012019 @default.
• W2025333501 countsByYear W20253335012020 @default.
• W2025333501 countsByYear W20253335012021 @default.
• W2025333501 countsByYear W20253335012022 @default.
• W2025333501 countsByYear W20253335012023 @default.
• W2025333501 crossrefType "journal-article" @default.
• W2025333501 hasAuthorship W2025333501A5019616762 @default.
• W2025333501 hasAuthorship W2025333501A5023194621 @default.
• W2025333501 hasAuthorship W2025333501A5027812322 @default.
• W2025333501 hasAuthorship W2025333501A5043619702 @default.
• W2025333501 hasAuthorship W2025333501A5045591505 @default.
• W2025333501 hasAuthorship W2025333501A5061870691 @default.
• W2025333501 hasAuthorship W2025333501A5064710593 @default.
• W2025333501 hasAuthorship W2025333501A5066189734 @default.
• W2025333501 hasAuthorship W2025333501A5069264476 @default.
• W2025333501 hasAuthorship W2025333501A5074833626 @default.
• W2025333501 hasConcept C126322002 @default.
• W2025333501 hasConcept C134018914 @default.
• W2025333501 hasConcept C2776617576 @default.
• W2025333501 hasConcept C2777180221 @default.
• W2025333501 hasConcept C2778854520 @default.
• W2025333501 hasConcept C2779306644 @default.
• W2025333501 hasConcept C2779768347 @default.
• W2025333501 hasConcept C2780323712 @default.
• W2025333501 hasConcept C2780473172 @default.
• W2025333501 hasConcept C555293320 @default.
• W2025333501 hasConcept C71924100 @default.
• W2025333501 hasConcept C98274493 @default.
• W2025333501 hasConceptScore W2025333501C126322002 @default.
• W2025333501 hasConceptScore W2025333501C134018914 @default.
• W2025333501 hasConceptScore W2025333501C2776617576 @default.
• W2025333501 hasConceptScore W2025333501C2777180221 @default.
• W2025333501 hasConceptScore W2025333501C2778854520 @default.
• W2025333501 hasConceptScore W2025333501C2779306644 @default.
• W2025333501 hasConceptScore W2025333501C2779768347 @default.
• W2025333501 hasConceptScore W2025333501C2780323712 @default.

• next