Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025334443> ?p ?o ?g. }
- W2025334443 endingPage "132" @default.
- W2025334443 startingPage "117" @default.
- W2025334443 abstract "The major dose-limiting toxicity of interleukin-2 (IL-2) and of immunotoxin (IT) therapies is vascular leak syndrome (VLS). VLS is characterized by an increase in vascular permeability accompanied by extravasation of fluids and proteins resulting in interstitial edema and organ failure. Manifestations of VLS include fluid retention, increase in body weight, peripheral edema, pleural and pericardial effusions, ascites, anasarca and, in severe form, signs of pulmonary and cardiovascular failure. Symptoms are highly variable among patients and the causes are poorly understood. The pathogenesis of endothelial cell (EC) damage is complex and can involve activation or damage to ECs and leukocytes, release of cytokines and of inflammatory mediators, alteration in cell-cell and cell-matrix adhesion and in cytoskeleton function. VLS restricts the doses of IL-2 and of ITs which can be administered to humans and, in some cases, necessitates the cessation of therapy. This review discusses the diversity of clinical manifestation, possible mechanisms and therapeutic modalities for VLS induced by IL-2 and ITs." @default.
- W2025334443 created "2016-06-24" @default.
- W2025334443 creator A5041874152 @default.
- W2025334443 creator A5084475433 @default.
- W2025334443 date "1997-10-01" @default.
- W2025334443 modified "2023-10-18" @default.
- W2025334443 title "Vascular leak syndrome: a side effect of immunotherapy" @default.
- W2025334443 cites W1444134552 @default.
- W2025334443 cites W1494575416 @default.
- W2025334443 cites W1510448495 @default.
- W2025334443 cites W1529386421 @default.
- W2025334443 cites W1541649993 @default.
- W2025334443 cites W1606334450 @default.
- W2025334443 cites W161035681 @default.
- W2025334443 cites W1635590414 @default.
- W2025334443 cites W1652390872 @default.
- W2025334443 cites W1829192223 @default.
- W2025334443 cites W1836425824 @default.
- W2025334443 cites W1843968746 @default.
- W2025334443 cites W1844068603 @default.
- W2025334443 cites W1893696425 @default.
- W2025334443 cites W1896820119 @default.
- W2025334443 cites W1904429763 @default.
- W2025334443 cites W1904436785 @default.
- W2025334443 cites W1938898757 @default.
- W2025334443 cites W1964824853 @default.
- W2025334443 cites W1966196375 @default.
- W2025334443 cites W1967768492 @default.
- W2025334443 cites W1968445389 @default.
- W2025334443 cites W1970429240 @default.
- W2025334443 cites W1971479549 @default.
- W2025334443 cites W1973306629 @default.
- W2025334443 cites W1974618377 @default.
- W2025334443 cites W1977096306 @default.
- W2025334443 cites W1977248032 @default.
- W2025334443 cites W1979974875 @default.
- W2025334443 cites W1981413761 @default.
- W2025334443 cites W1981912238 @default.
- W2025334443 cites W1986100755 @default.
- W2025334443 cites W1986580574 @default.
- W2025334443 cites W1987209474 @default.
- W2025334443 cites W1996279472 @default.
- W2025334443 cites W1998421401 @default.
- W2025334443 cites W2001474547 @default.
- W2025334443 cites W2001613674 @default.
- W2025334443 cites W2003559448 @default.
- W2025334443 cites W2003879163 @default.
- W2025334443 cites W2008557677 @default.
- W2025334443 cites W2009705735 @default.
- W2025334443 cites W2011477764 @default.
- W2025334443 cites W2011980552 @default.
- W2025334443 cites W2013458237 @default.
- W2025334443 cites W2014352552 @default.
- W2025334443 cites W2014977460 @default.
- W2025334443 cites W2016092001 @default.
- W2025334443 cites W2017842784 @default.
- W2025334443 cites W2018931269 @default.
- W2025334443 cites W2021311410 @default.
- W2025334443 cites W2021977722 @default.
- W2025334443 cites W2023362132 @default.
- W2025334443 cites W2025586271 @default.
- W2025334443 cites W2030463613 @default.
- W2025334443 cites W2031994009 @default.
- W2025334443 cites W2032288970 @default.
- W2025334443 cites W2034637957 @default.
- W2025334443 cites W2034754045 @default.
- W2025334443 cites W2037860153 @default.
- W2025334443 cites W2040140105 @default.
- W2025334443 cites W2041231796 @default.
- W2025334443 cites W2042794195 @default.
- W2025334443 cites W2043347750 @default.
- W2025334443 cites W2044731850 @default.
- W2025334443 cites W2046068762 @default.
- W2025334443 cites W2047328898 @default.
- W2025334443 cites W2048395992 @default.
- W2025334443 cites W2049473901 @default.
- W2025334443 cites W2049775682 @default.
- W2025334443 cites W2061860464 @default.
- W2025334443 cites W206283783 @default.
- W2025334443 cites W2065538879 @default.
- W2025334443 cites W2066442012 @default.
- W2025334443 cites W2067431754 @default.
- W2025334443 cites W2068025787 @default.
- W2025334443 cites W2069147546 @default.
- W2025334443 cites W2069430512 @default.
- W2025334443 cites W2070552857 @default.
- W2025334443 cites W2076559511 @default.
- W2025334443 cites W2078149048 @default.
- W2025334443 cites W2078429706 @default.
- W2025334443 cites W2079289760 @default.
- W2025334443 cites W2080306831 @default.
- W2025334443 cites W2082858960 @default.
- W2025334443 cites W2082871972 @default.
- W2025334443 cites W2083915079 @default.
- W2025334443 cites W2084568666 @default.
- W2025334443 cites W2084589493 @default.
- W2025334443 cites W2086276601 @default.
- W2025334443 cites W2087270937 @default.