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- W2025335909 abstract "The purpose of the study was to estimate the prevalence and determinants of distinct patterns of left ventricular remodeling in hypertensive patients in St.Petersburg population and their relation to intima-media thickness (IMT) and endothelial function of the arteries. A cross-sectional study in a population-based sample of 734 essential hypertensives from the primary care clinic was undertaken. Echocardiography was performed and analyzed by trained observers. The left ventricular posterior wall thickness (PW), interventricular septum (IVS) and left ventricular mass index (LVMI) were measured. High resolution B-mode ultrasound was used to determine IMT (the mean of 12 measurements), Vascular ultrasound was performed to measure the brachial artery diameter during reactive hyperaemia test and analysis of endothelium-dependent vasodilatation. Left ventricular hypertrophy (LVH) was more prevalent in women than in men (67,4 vs 57,4%, χ2= 8,8, p<0,05). Normal geometry was diagnosed in 217 patients (30%), concentric LVH in 238 (32%), eccentric one in 230 (31%) and concentric remodeling in 49 (7%).The proportion of concentric hypertrophy increased from mild to severe hypertension (18 to 66%). Sex, obesity stage and type, and hypertension level and duration contributed to LVH level and remodeling pattern. Parameters of vascular ultrasound differed significantly in different remodeling patterns. IMT thickness was higher in concentric LVH group (1,03±0,21 comared to 0,79±0,16 in normal geometry pattern, as well as to 0,93±0,08 in eccentric LVH, p<0.01). The same tendency was observed concerning endothelial fucntion. Endothelial-dependent vasodilatation (EDVD) was significantly reduced in concentric LVH (4,1±0,6%) compared to eccentric LVH (5,0±0,9) (p<0.01). Thus, the pattern of LV geometry in hypertension seems to be determined by the level of hypertension as well as gender and obesity type. Vascular remodeling and endothelial dysfunction seems to be associated with LV remodeling pattern, being more severe in concentric LVH. Am J Hypertens (2004) 17, 86A–86A; doi: 10.1016/j.amjhyper.2004.03.220" @default.
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- W2025335909 date "2004-05-01" @default.
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- W2025335909 title "Left ventricular remodeling, carotid intima-media thickness and endothelial fuction in untreated hypertensive patients" @default.
- W2025335909 doi "https://doi.org/10.1016/j.amjhyper.2004.03.220" @default.
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