FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025336457> ?p ?o ?g. }

• W2025336457 endingPage "4621" @default.
• W2025336457 startingPage "4608" @default.
• W2025336457 abstract "The active metabolite (2) of the novel immunosuppressive agent leflunomide (1) has been shown to inhibit the enzyme dihydroorotate dehydrogenase (DHODH). This enzyme catalyzes the fourth step in de novo pyrimidine biosynthesis. A series of analogues of the active metabolite 2 have been synthesized. Their in vivo biological activity determined in rat and mouse delayed type hypersensitivity has been found to correlate well with their in vitro DHODH potency. The most promising compound (3) has shown activity in rat and mouse collagen (II)-induced arthritis models (ED50 = 2 and 31 mg/kg, respectively) and has shown a shorter half-life in man when compared with leflunomide. Clinical studies in rheumatoid arthritis are in progress." @default.
• W2025336457 created "2016-06-24" @default.
• W2025336457 creator A5009371755 @default.
• W2025336457 creator A5009371838 @default.
• W2025336457 creator A5014966771 @default.
• W2025336457 creator A5016438933 @default.
• W2025336457 creator A5024110321 @default.
• W2025336457 creator A5032969159 @default.
• W2025336457 creator A5042831360 @default.
• W2025336457 creator A5053067336 @default.
• W2025336457 creator A5057510564 @default.
• W2025336457 creator A5068046950 @default.
• W2025336457 creator A5076326133 @default.
• W2025336457 creator A5078988280 @default.
• W2025336457 creator A5079053463 @default.
• W2025336457 creator A5086912710 @default.
• W2025336457 creator A5089164675 @default.
• W2025336457 creator A5091175904 @default.
• W2025336457 date "1996-01-01" @default.
• W2025336457 modified "2023-09-26" @default.
• W2025336457 title "Synthesis, Structure−Activity Relationships, and Pharmacokinetic Properties of Dihydroorotate Dehydrogenase Inhibitors: 2-Cyano-3-cyclopropyl-3-hydroxy- <i>N</i>-[3‘-methyl-4‘-(trifluoromethyl)phenyl]propenamide and Related Compounds" @default.
• W2025336457 cites W1964717435 @default.
• W2025336457 cites W2006067737 @default.
• W2025336457 cites W2050000814 @default.
• W2025336457 cites W2075725934 @default.
• W2025336457 cites W2079184949 @default.
• W2025336457 cites W2088740230 @default.
• W2025336457 cites W2118188929 @default.
• W2025336457 cites W2126044426 @default.
• W2025336457 cites W2150844359 @default.
• W2025336457 cites W2161341063 @default.
• W2025336457 cites W2162166182 @default.
• W2025336457 cites W2326789779 @default.
• W2025336457 doi "https://doi.org/10.1021/jm9604437" @default.
• W2025336457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8917650" @default.
• W2025336457 hasPublicationYear "1996" @default.
• W2025336457 type Work @default.
• W2025336457 sameAs 2025336457 @default.
• W2025336457 citedByCount "84" @default.
• W2025336457 countsByYear W20253364572012 @default.
• W2025336457 countsByYear W20253364572013 @default.
• W2025336457 countsByYear W20253364572014 @default.
• W2025336457 countsByYear W20253364572015 @default.
• W2025336457 countsByYear W20253364572018 @default.
• W2025336457 countsByYear W20253364572019 @default.
• W2025336457 countsByYear W20253364572020 @default.
• W2025336457 countsByYear W20253364572021 @default.
• W2025336457 countsByYear W20253364572022 @default.
• W2025336457 crossrefType "journal-article" @default.
• W2025336457 hasAuthorship W2025336457A5009371755 @default.
• W2025336457 hasAuthorship W2025336457A5009371838 @default.
• W2025336457 hasAuthorship W2025336457A5014966771 @default.
• W2025336457 hasAuthorship W2025336457A5016438933 @default.
• W2025336457 hasAuthorship W2025336457A5024110321 @default.
• W2025336457 hasAuthorship W2025336457A5032969159 @default.
• W2025336457 hasAuthorship W2025336457A5042831360 @default.
• W2025336457 hasAuthorship W2025336457A5053067336 @default.
• W2025336457 hasAuthorship W2025336457A5057510564 @default.
• W2025336457 hasAuthorship W2025336457A5068046950 @default.
• W2025336457 hasAuthorship W2025336457A5076326133 @default.
• W2025336457 hasAuthorship W2025336457A5078988280 @default.
• W2025336457 hasAuthorship W2025336457A5079053463 @default.
• W2025336457 hasAuthorship W2025336457A5086912710 @default.
• W2025336457 hasAuthorship W2025336457A5089164675 @default.
• W2025336457 hasAuthorship W2025336457A5091175904 @default.
• W2025336457 hasConcept C116073593 @default.
• W2025336457 hasConcept C149151106 @default.
• W2025336457 hasConcept C150903083 @default.
• W2025336457 hasConcept C178790620 @default.
• W2025336457 hasConcept C181199279 @default.
• W2025336457 hasConcept C185592680 @default.
• W2025336457 hasConcept C193042331 @default.
• W2025336457 hasConcept C200159599 @default.
• W2025336457 hasConcept C202751555 @default.
• W2025336457 hasConcept C203014093 @default.
• W2025336457 hasConcept C207001950 @default.
• W2025336457 hasConcept C2775905006 @default.
• W2025336457 hasConcept C2776317432 @default.
• W2025336457 hasConcept C2776442012 @default.
• W2025336457 hasConcept C2776476023 @default.
• W2025336457 hasConcept C2776980637 @default.
• W2025336457 hasConcept C2777477808 @default.
• W2025336457 hasConcept C2777575956 @default.
• W2025336457 hasConcept C2779321679 @default.
• W2025336457 hasConcept C2779865431 @default.
• W2025336457 hasConcept C2780263894 @default.
• W2025336457 hasConcept C42533223 @default.
• W2025336457 hasConcept C55493867 @default.
• W2025336457 hasConcept C57992300 @default.
• W2025336457 hasConcept C71240020 @default.
• W2025336457 hasConcept C71924100 @default.
• W2025336457 hasConcept C86803240 @default.
• W2025336457 hasConcept C98274493 @default.
• W2025336457 hasConceptScore W2025336457C116073593 @default.
• W2025336457 hasConceptScore W2025336457C149151106 @default.
• W2025336457 hasConceptScore W2025336457C150903083 @default.
• W2025336457 hasConceptScore W2025336457C178790620 @default.
• W2025336457 hasConceptScore W2025336457C181199279 @default.

• next