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• W2025341212 startingPage "e112449" @default.
• W2025341212 abstract "As a result of the genetic selection of broiler (meat-type breeders) chickens for enhanced growth rate and lower feed conversion ratio, it has become necessary to restrict feed intake. When broilers are fed ad libitum, they would become obese and suffer from several health-related problems. A vital adaptation to starvation is autophagy, a self-eating mechanism for recycling cellular constituents. The autophagy pathway has witnessed dramatic growth in the last few years and extensively studied in yeast and mammals however, there is a paucity of information in avian (non-mammalian) species. Here we characterized several genes involved in autophagosome initiation and elongation in Red Jungle fowl (Gallus gallus) and Japanese quail (coturnix coturnix Japonica). Both complexes are ubiquitously expressed in chicken and quail tissues (liver, leg and breast muscle, brain, gizzard, intestine, heart, lung, kidney, adipose tissue, ovary and testis). Alignment analysis showed high similarity (50.7 to 91.5%) between chicken autophagy-related genes and their mammalian orthologs. Phylogenetic analysis demonstrated that the evolutionary relationship between autophagy genes is consistent with the consensus view of vertebrate evolution. Interestingly, the expression of autophagy-related genes is tissue- and gender-dependent. Furthermore, using two experimental male quail lines divergently selected over 40 generations for low (resistant, R) or high (sensitive, S) stress response, we found that the expression of most studied genes are higher in R compared to S line. Together our results indicate that the autophagy pathway is a key molecular signature exhibited gender specific differences and likely plays an important role in response to stress in avian species." @default.
• W2025341212 created "2016-06-24" @default.
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• W2025341212 date "2014-11-11" @default.
• W2025341212 modified "2023-10-18" @default.
• W2025341212 title "Tissue Distribution, Gender- and Genotype-Dependent Expression of Autophagy-Related Genes in Avian Species" @default.
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• W2025341212 doi "https://doi.org/10.1371/journal.pone.0112449" @default.
• W2025341212 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4227737" @default.
• W2025341212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25386921" @default.
• W2025341212 hasPublicationYear "2014" @default.
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