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• W2025342203 abstract "The frequency of autopsies appears to be declining, and the usefulness has been challenged. We reviewed cases of autopsied active infective endocarditis (IE) during 2 periods based on the availability of high-tech 2-dimensional echocardiograms: Period 1 (P1) included 40 cases studied from 1970 to 1985, and Period 2 (P2) included 28 cases seen from 1986 to 2008—that is, before and after the introduction of echocardiograms in our institution. We conducted the study to reassess the pathology of IE and to determine how frequently diagnosis is not made during life. The age of patients increased 10 years on average between the 2 periods, and comorbidities were significantly more frequent in P2. While the frequency of rheumatic valve disease and prosthetic valve endocarditis (PVE) decreased, degenerative valve disease increased. Isolated mitral or aortic valve IE was most common. Right-sided IE was observed in patients with Staphylococcus aureus bacteremia from infected venous lines. In most cases IE involved only the cusps of cardiac valves. “Virulent” microorganisms caused ulcerations, rupture, and perforation of the cusps and necrosis of chordae tendiniae and perivalvular apparatus. In PVE the lesions were located behind the site of attachment, and vegetations were seen on the sewing ring in both metallic and biologic prostheses. Infection spread to adjacent structures and myocardium with ring abscess observed in 88% of cases. Prosthetic detachment causing valve regurgitation was associated with abscesses in 76% of cases; these patients developed persistent sepsis and severe cardiac failure. Obstruction occurred in patients with PVE of the mitral valve. Acute purulent pericarditis was observed in 22% of cases, mainly in patients with aortic valve IE and myocardial abscesses. Gross infarcts were seen in 63% of cases but were asymptomatic in most instances. The spleen, kidneys, and mesentery were the sites most frequently involved. Myocardial infarctions were found in less than 10% of cases. Abscesses were also frequently found and were a common source of persistent fever and bacteremia. Glomerulonephritis was more common in the first period. Brain pathology consisted of ischemic and hemorrhagic infarcts and abscesses. Cerebral bleeding was more frequent in patients with PVE on anticoagulant therapy. Neutrophilic meningitis was observed in S. aureus IE. Diagnosis of IE was not made during life in 14 (35%) cases during P1 and 12 (42.8%) cases in P2. Overall, diagnosis was missed until autopsy in 38.2% of cases. IE was hospital acquired in 28 instances. While a clinical diagnosis was made in all but 4 cases of early-onset PVE (23.5%), the diagnosis was not made during life in 22 of 51 patients with native-valve IE (43.1%). Of these 22 patients, IE was hospital acquired in 11 (50%). The absence of fever, cardiac murmurs, and many of the typical stigmata of endocarditis may have led to the diagnosis being overlooked clinically. Brain bleeding, cardiac failure and less frequently acute myocardial infarct were the most common causes of death. IE continues to be missed frequently until autopsy. Postmortem examination is an important tool for evaluating the quality of care, and for guiding teaching and research related to cardiovascular infections. Abbreviations CT = computed tomography, IE = infective endocarditis, MRI = magnetic resonance imaging, P1 = Period 1, P2 = Period 2, PVE = prosthetic valve endocarditis, TTE = transthoracic echocardiogram, TEE = transesophageal echocardiogram." @default.
• W2025342203 created "2016-06-24" @default.
• W2025342203 creator A5036013164 @default.
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• W2025342203 creator A5055509429 @default.
• W2025342203 creator A5071077565 @default.
• W2025342203 date "2012-05-01" @default.
• W2025342203 modified "2023-10-01" @default.
• W2025342203 title "Infective Endocarditis at Autopsy" @default.
• W2025342203 cites W1502081823 @default.
• W2025342203 cites W1509966405 @default.
• W2025342203 cites W1510405451 @default.
• W2025342203 cites W1518606463 @default.
• W2025342203 cites W1552861013 @default.
• W2025342203 cites W1595457782 @default.
• W2025342203 cites W1599775733 @default.
• W2025342203 cites W1965788692 @default.
• W2025342203 cites W1966186793 @default.
• W2025342203 cites W1966865914 @default.
• W2025342203 cites W1969355272 @default.
• W2025342203 cites W1971072605 @default.
• W2025342203 cites W1977906308 @default.
• W2025342203 cites W1980676893 @default.
• W2025342203 cites W1983659762 @default.
• W2025342203 cites W1985192378 @default.
• W2025342203 cites W1988296160 @default.
• W2025342203 cites W1988802261 @default.
• W2025342203 cites W1989631902 @default.
• W2025342203 cites W1990740789 @default.
• W2025342203 cites W1991495943 @default.
• W2025342203 cites W1999634356 @default.
• W2025342203 cites W2003821210 @default.
• W2025342203 cites W2011034598 @default.
• W2025342203 cites W2021279472 @default.
• W2025342203 cites W2022647033 @default.
• W2025342203 cites W2023876883 @default.
• W2025342203 cites W2025751743 @default.
• W2025342203 cites W2030417654 @default.
• W2025342203 cites W2032807806 @default.
• W2025342203 cites W2042945782 @default.
• W2025342203 cites W2045536326 @default.
• W2025342203 cites W2055312241 @default.
• W2025342203 cites W2057352262 @default.
• W2025342203 cites W2058069754 @default.
• W2025342203 cites W2065816509 @default.
• W2025342203 cites W2067185841 @default.
• W2025342203 cites W2071298942 @default.
• W2025342203 cites W2073407652 @default.
• W2025342203 cites W2075221007 @default.
• W2025342203 cites W2075834299 @default.
• W2025342203 cites W2080162249 @default.
• W2025342203 cites W2081623389 @default.
• W2025342203 cites W2081643018 @default.
• W2025342203 cites W2081964574 @default.
• W2025342203 cites W2083134176 @default.
• W2025342203 cites W2087287660 @default.
• W2025342203 cites W2091761897 @default.
• W2025342203 cites W2096009044 @default.
• W2025342203 cites W2097251588 @default.
• W2025342203 cites W2110914596 @default.
• W2025342203 cites W2114240299 @default.
• W2025342203 cites W2124355041 @default.
• W2025342203 cites W2125527439 @default.
• W2025342203 cites W2127239282 @default.
• W2025342203 cites W2142716654 @default.
• W2025342203 cites W2142848829 @default.
• W2025342203 cites W2146469326 @default.
• W2025342203 cites W2147318504 @default.
• W2025342203 cites W2147390013 @default.
• W2025342203 cites W2147435328 @default.
• W2025342203 cites W2151950267 @default.
• W2025342203 cites W2153989479 @default.
• W2025342203 cites W2156451821 @default.
• W2025342203 cites W2156742574 @default.
• W2025342203 cites W2157572113 @default.
• W2025342203 cites W2171068899 @default.
• W2025342203 cites W2330866081 @default.
• W2025342203 cites W2336318432 @default.
• W2025342203 cites W2428421205 @default.
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• W2025342203 doi "https://doi.org/10.1097/md.0b013e31825631ea" @default.
• W2025342203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22543628" @default.
• W2025342203 hasPublicationYear "2012" @default.
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