Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025343480> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2025343480 endingPage "345" @default.
- W2025343480 startingPage "337" @default.
- W2025343480 abstract "To date, no effective therapeutic treatment prevents prostate cancer (PCa) progression to more advanced and invasive disease forms. It has been demonstrated that the simultaneous high expression of p185(HER2) and TrkA might confer a proliferative advantage to PCa cells.In this work we verified the crosstalk between TrkA and Her2 signaling pathways and the effects of a combined treatment with Her2 and TrkA inhibitors.NGF induced TrkA activation and stimulated cell proliferation of PCa cells. NGF induced also tyrosine phosphorylation of p185(HER2). This event was only partially inhibited by the pan Trk inhibitor, CEP-701 but was strongly blocked by pertuzumab, a humanized antibody blocking Her2 heterodimerization. In presence of NGF, TrkA and Her2 co-precipitated and this was dependent to the relative high cellular levels of TrkA since when cell lysates were immunoprecipitated with an antibody against Her2 the amount of TrkA were proportional to the cellular levels of this receptor. On the contrary when we immunoprecipitated using an antibody against TrkA the amount of Her2 seemed independent to cellular levels of Her2. So, combined treatment between CEP-701 and pertuzumab showed supra-additive effects in cells with higher levels of TrkA and Her2 suggesting once again that this was indicative of a higher response to treatment.Our data suggest that the dual inhibition of TrkA and Her2 may be useful in a subset of patients in which TrkA and Her2 are overexpressed and in which the possibility of TrkA and Her2 protein-binding is elevated." @default.
- W2025343480 created "2016-06-24" @default.
- W2025343480 creator A5002876711 @default.
- W2025343480 creator A5006143315 @default.
- W2025343480 creator A5007388030 @default.
- W2025343480 creator A5020344479 @default.
- W2025343480 creator A5034652512 @default.
- W2025343480 creator A5046639860 @default.
- W2025343480 creator A5056945588 @default.
- W2025343480 creator A5073387430 @default.
- W2025343480 creator A5082847339 @default.
- W2025343480 date "2008-11-14" @default.
- W2025343480 modified "2023-09-24" @default.
- W2025343480 title "Her2 crosstalks with TrkA in a subset of prostate cancer cells: Rationale for a guided dual treatment" @default.
- W2025343480 cites W1524260332 @default.
- W2025343480 cites W1965876887 @default.
- W2025343480 cites W1971601647 @default.
- W2025343480 cites W197699128 @default.
- W2025343480 cites W1981692950 @default.
- W2025343480 cites W1982273913 @default.
- W2025343480 cites W1999886002 @default.
- W2025343480 cites W2001447115 @default.
- W2025343480 cites W2006968122 @default.
- W2025343480 cites W2023097049 @default.
- W2025343480 cites W2028727039 @default.
- W2025343480 cites W2043758576 @default.
- W2025343480 cites W2044883891 @default.
- W2025343480 cites W2045304682 @default.
- W2025343480 cites W2051942339 @default.
- W2025343480 cites W2055798475 @default.
- W2025343480 cites W2071378820 @default.
- W2025343480 cites W2072077210 @default.
- W2025343480 cites W2120946253 @default.
- W2025343480 cites W2125403403 @default.
- W2025343480 cites W2131931560 @default.
- W2025343480 cites W2140382280 @default.
- W2025343480 cites W2151313224 @default.
- W2025343480 cites W2413497817 @default.
- W2025343480 cites W4317528183 @default.
- W2025343480 doi "https://doi.org/10.1002/pros.20884" @default.
- W2025343480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19016477" @default.
- W2025343480 hasPublicationYear "2008" @default.
- W2025343480 type Work @default.
- W2025343480 sameAs 2025343480 @default.
- W2025343480 citedByCount "10" @default.
- W2025343480 countsByYear W20253434802015 @default.
- W2025343480 countsByYear W20253434802016 @default.
- W2025343480 countsByYear W20253434802018 @default.
- W2025343480 countsByYear W20253434802019 @default.
- W2025343480 countsByYear W20253434802021 @default.
- W2025343480 crossrefType "journal-article" @default.
- W2025343480 hasAuthorship W2025343480A5002876711 @default.
- W2025343480 hasAuthorship W2025343480A5006143315 @default.
- W2025343480 hasAuthorship W2025343480A5007388030 @default.
- W2025343480 hasAuthorship W2025343480A5020344479 @default.
- W2025343480 hasAuthorship W2025343480A5034652512 @default.
- W2025343480 hasAuthorship W2025343480A5046639860 @default.
- W2025343480 hasAuthorship W2025343480A5056945588 @default.
- W2025343480 hasAuthorship W2025343480A5073387430 @default.
- W2025343480 hasAuthorship W2025343480A5082847339 @default.
- W2025343480 hasConcept C126322002 @default.
- W2025343480 hasConcept C134139212 @default.
- W2025343480 hasConcept C170493617 @default.
- W2025343480 hasConcept C171034665 @default.
- W2025343480 hasConcept C2778423431 @default.
- W2025343480 hasConcept C502942594 @default.
- W2025343480 hasConcept C56703729 @default.
- W2025343480 hasConcept C71924100 @default.
- W2025343480 hasConcept C86803240 @default.
- W2025343480 hasConceptScore W2025343480C126322002 @default.
- W2025343480 hasConceptScore W2025343480C134139212 @default.
- W2025343480 hasConceptScore W2025343480C170493617 @default.
- W2025343480 hasConceptScore W2025343480C171034665 @default.
- W2025343480 hasConceptScore W2025343480C2778423431 @default.
- W2025343480 hasConceptScore W2025343480C502942594 @default.
- W2025343480 hasConceptScore W2025343480C56703729 @default.
- W2025343480 hasConceptScore W2025343480C71924100 @default.
- W2025343480 hasConceptScore W2025343480C86803240 @default.
- W2025343480 hasIssue "4" @default.
- W2025343480 hasLocation W20253434801 @default.
- W2025343480 hasLocation W20253434802 @default.
- W2025343480 hasOpenAccess W2025343480 @default.
- W2025343480 hasPrimaryLocation W20253434801 @default.
- W2025343480 hasRelatedWork W1864822730 @default.
- W2025343480 hasRelatedWork W1993713261 @default.
- W2025343480 hasRelatedWork W2041171950 @default.
- W2025343480 hasRelatedWork W2042762326 @default.
- W2025343480 hasRelatedWork W2058199689 @default.
- W2025343480 hasRelatedWork W2081555648 @default.
- W2025343480 hasRelatedWork W2138688715 @default.
- W2025343480 hasRelatedWork W2164406482 @default.
- W2025343480 hasRelatedWork W2357404056 @default.
- W2025343480 hasRelatedWork W748976835 @default.
- W2025343480 hasVolume "69" @default.
- W2025343480 isParatext "false" @default.
- W2025343480 isRetracted "false" @default.
- W2025343480 magId "2025343480" @default.
- W2025343480 workType "article" @default.