Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025344981> ?p ?o ?g. }
- W2025344981 endingPage "F783" @default.
- W2025344981 startingPage "F774" @default.
- W2025344981 abstract "Overnutrition during pre- and postnatal development both confer increased susceptibility to renal and metabolic risks later in life; however, whether they have an additive effect on the severity of renal and metabolic injury remains unknown. The present study tested the hypothesis that a combination of a pre- and postnatal diet high in fat/fructose would exacerbate renal and metabolic injury in male offspring later in life. Male offspring born to high fat/high-fructose-fed mothers and fed a high-fat/high-fructose diet postnatally (HF-HF) had increased urine albumin excretion (450%), glomerulosclerosis (190%), and tubulointerstitial fibrosis (101%) compared with offspring born to mothers fed a standard diet and fed a standard diet postnatally (NF-NF). No changes in blood pressure or glomerular filtration were observed between any of the treatment groups. The HF-HF offspring weighed ∼23% more than offspring born to mothers fed a high-fat/high-fructose diet and fed a normal diet postnatally (HF-NF), as well as offspring born to mothers fed a standard diet regardless of their postnatal diet. The HF-HF rats also had increased (and more variable) blood glucose levels over 12 wk of being fed a high-fat/high-fructose diet. A combination of exposure to a high-fat/high-fructose diet in utero and postnatally increased plasma insulin levels by 140% compared with NF-NF offspring. Our data suggest that the combined exposure to overnutrition during fetal development and early postnatal development potentiate the susceptibility to renal and metabolic disturbances later in life." @default.
- W2025344981 created "2016-06-24" @default.
- W2025344981 creator A5007422078 @default.
- W2025344981 creator A5009002227 @default.
- W2025344981 creator A5028949350 @default.
- W2025344981 creator A5051832266 @default.
- W2025344981 creator A5070679221 @default.
- W2025344981 creator A5070826933 @default.
- W2025344981 creator A5076525960 @default.
- W2025344981 creator A5078543740 @default.
- W2025344981 date "2012-03-15" @default.
- W2025344981 modified "2023-10-04" @default.
- W2025344981 title "Exposure to maternal overnutrition and a high-fat diet during early postnatal development increases susceptibility to renal and metabolic injury later in life" @default.
- W2025344981 cites W2004145345 @default.
- W2025344981 cites W2009179022 @default.
- W2025344981 cites W2032139066 @default.
- W2025344981 cites W2043603348 @default.
- W2025344981 cites W2045418967 @default.
- W2025344981 cites W2046859247 @default.
- W2025344981 cites W2047632739 @default.
- W2025344981 cites W2049928574 @default.
- W2025344981 cites W2060936195 @default.
- W2025344981 cites W2064497302 @default.
- W2025344981 cites W2077944070 @default.
- W2025344981 cites W2085574022 @default.
- W2025344981 cites W2095656037 @default.
- W2025344981 cites W2099696895 @default.
- W2025344981 cites W2100695272 @default.
- W2025344981 cites W2101626292 @default.
- W2025344981 cites W2113495407 @default.
- W2025344981 cites W2115716260 @default.
- W2025344981 cites W2117686645 @default.
- W2025344981 cites W2118705787 @default.
- W2025344981 cites W2119741758 @default.
- W2025344981 cites W2121804122 @default.
- W2025344981 cites W2121832007 @default.
- W2025344981 cites W2127874524 @default.
- W2025344981 cites W2131017300 @default.
- W2025344981 cites W2134510811 @default.
- W2025344981 cites W2136843578 @default.
- W2025344981 cites W2136958766 @default.
- W2025344981 cites W2154990899 @default.
- W2025344981 cites W2169530323 @default.
- W2025344981 cites W2417047841 @default.
- W2025344981 cites W2588237306 @default.
- W2025344981 cites W44110801 @default.
- W2025344981 doi "https://doi.org/10.1152/ajprenal.00491.2011" @default.
- W2025344981 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3311311" @default.
- W2025344981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22160775" @default.
- W2025344981 hasPublicationYear "2012" @default.
- W2025344981 type Work @default.
- W2025344981 sameAs 2025344981 @default.
- W2025344981 citedByCount "44" @default.
- W2025344981 countsByYear W20253449812012 @default.
- W2025344981 countsByYear W20253449812013 @default.
- W2025344981 countsByYear W20253449812014 @default.
- W2025344981 countsByYear W20253449812015 @default.
- W2025344981 countsByYear W20253449812016 @default.
- W2025344981 countsByYear W20253449812017 @default.
- W2025344981 countsByYear W20253449812018 @default.
- W2025344981 countsByYear W20253449812019 @default.
- W2025344981 countsByYear W20253449812020 @default.
- W2025344981 countsByYear W20253449812022 @default.
- W2025344981 crossrefType "journal-article" @default.
- W2025344981 hasAuthorship W2025344981A5007422078 @default.
- W2025344981 hasAuthorship W2025344981A5009002227 @default.
- W2025344981 hasAuthorship W2025344981A5028949350 @default.
- W2025344981 hasAuthorship W2025344981A5051832266 @default.
- W2025344981 hasAuthorship W2025344981A5070679221 @default.
- W2025344981 hasAuthorship W2025344981A5070826933 @default.
- W2025344981 hasAuthorship W2025344981A5076525960 @default.
- W2025344981 hasAuthorship W2025344981A5078543740 @default.
- W2025344981 hasBestOaLocation W20253449812 @default.
- W2025344981 hasConcept C112672928 @default.
- W2025344981 hasConcept C126322002 @default.
- W2025344981 hasConcept C134018914 @default.
- W2025344981 hasConcept C2778302649 @default.
- W2025344981 hasConcept C2779234561 @default.
- W2025344981 hasConcept C2780655333 @default.
- W2025344981 hasConcept C511355011 @default.
- W2025344981 hasConcept C54355233 @default.
- W2025344981 hasConcept C71924100 @default.
- W2025344981 hasConcept C86803240 @default.
- W2025344981 hasConceptScore W2025344981C112672928 @default.
- W2025344981 hasConceptScore W2025344981C126322002 @default.
- W2025344981 hasConceptScore W2025344981C134018914 @default.
- W2025344981 hasConceptScore W2025344981C2778302649 @default.
- W2025344981 hasConceptScore W2025344981C2779234561 @default.
- W2025344981 hasConceptScore W2025344981C2780655333 @default.
- W2025344981 hasConceptScore W2025344981C511355011 @default.
- W2025344981 hasConceptScore W2025344981C54355233 @default.
- W2025344981 hasConceptScore W2025344981C71924100 @default.
- W2025344981 hasConceptScore W2025344981C86803240 @default.
- W2025344981 hasIssue "6" @default.
- W2025344981 hasLocation W20253449811 @default.
- W2025344981 hasLocation W20253449812 @default.
- W2025344981 hasLocation W20253449813 @default.
- W2025344981 hasLocation W20253449814 @default.