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- W2025347722 abstract "SummaryNeonatal herpes simplex virus infection is rare but potentially fatal. Most infections are acquired at birth and are caused by herpes simplex type 2 (HSV-2). Antepartum maternal cultures fail to predict a baby's risk of exposure to the virus at delivery. Alternative strategies include: (a) antenatal screening for antibodies to HSV-2 and the selective use of intrapartum direct virus detection; and (b) selective antenatal use of acyclovir.Neonatal herpes simplex infections are relatively rare in the United Kingdom, occurring in 1 -9 (95 per cent confidence interval 1 -4 to 2-5) per 100 000 live births (British Paediatric Surveillance Unit, 1991) compared with up to 26 per 100 000 in the United States of America (Chuang, 1988). They have a mortality rate of approximately 50 per cent and cause serious permanent morbidity including ocular and psychomotor retardation in 50 per cent of survivors (Nahmias et al., 1970). Most neonatal infections are acquired during delivery (Nahmias et al., 1970) with active maternal genital herpes infection, especially if primary, as the most important risk factor. Herpes simplex type 2 (HSV-2) is responsible for 90 per cent of primary and 99 per cent of recurrent genital herpes infection, and for 80 per cent of neonatal herpes infection, with more serious ocular and central nervous system sequelae than are seen with type 1." @default.
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- W2025347722 date "1995-01-01" @default.
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- W2025347722 title "Genital herpes simplex virus infection in pregnancy: new proposals to improve screening and reduce neonatal risk" @default.
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- W2025347722 doi "https://doi.org/10.3109/01443619509015484" @default.
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