FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025363689> ?p ?o ?g. }

• W2025363689 endingPage "357" @default.
• W2025363689 startingPage "344" @default.
• W2025363689 abstract "In mice the transcription factor Elf5 is necessary for correct trophoblast development. Upon knockdown of Elf5, TS cells display neither a decrease in proliferation nor an increase in cell death but rather an increased propensity to differentiate. Such cells rapidly lose Sox2 and 3 expression, while transiently upregulating the giant cell differentiation determinant gene Hand1. Other genes affected within 24h of Elf5 knock-down, many of which have not previously been implicated in trophoblast development, exhibited in vivo expression domains and in vitro expression responses consistent with Elf5 having a role in counteracting trophoblast differentiation. In an ES to TS differentiation assay using Cdx2 overexpression with Elf5 loss of function cell lines, it was shown that Elf5 is necessary to prevent terminal trophoblast differentiation. This data thus suggest that Elf5 is a gatekeeper for the TS to differentiated trophoblast transition thereby preventing the precocious differentiation of the undifferentiated extraembryonic ectoderm." @default.
• W2025363689 created "2016-06-24" @default.
• W2025363689 creator A5043041515 @default.
• W2025363689 creator A5046335803 @default.
• W2025363689 creator A5071838590 @default.
• W2025363689 creator A5076571566 @default.
• W2025363689 creator A5088573553 @default.
• W2025363689 creator A5090823805 @default.
• W2025363689 date "2014-08-01" @default.
• W2025363689 modified "2023-10-15" @default.
• W2025363689 title "Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 and 3 and inhibiting Hand1 expression" @default.
• W2025363689 cites W1599762863 @default.
• W2025363689 cites W1897016067 @default.
• W2025363689 cites W1970062529 @default.
• W2025363689 cites W1971592610 @default.
• W2025363689 cites W1974307668 @default.
• W2025363689 cites W1974651870 @default.
• W2025363689 cites W1975751233 @default.
• W2025363689 cites W1997119504 @default.
• W2025363689 cites W2001090533 @default.
• W2025363689 cites W2001848617 @default.
• W2025363689 cites W2014691022 @default.
• W2025363689 cites W2023508819 @default.
• W2025363689 cites W2025594663 @default.
• W2025363689 cites W2033391319 @default.
• W2025363689 cites W2041799836 @default.
• W2025363689 cites W2043980237 @default.
• W2025363689 cites W2055664397 @default.
• W2025363689 cites W2059994388 @default.
• W2025363689 cites W2060928558 @default.
• W2025363689 cites W2062261618 @default.
• W2025363689 cites W2066911215 @default.
• W2025363689 cites W2071353985 @default.
• W2025363689 cites W2074972224 @default.
• W2025363689 cites W2088237277 @default.
• W2025363689 cites W2092180000 @default.
• W2025363689 cites W2092392797 @default.
• W2025363689 cites W2097248071 @default.
• W2025363689 cites W2098094337 @default.
• W2025363689 cites W2101881948 @default.
• W2025363689 cites W2113368077 @default.
• W2025363689 cites W2119340477 @default.
• W2025363689 cites W2123829995 @default.
• W2025363689 cites W2131586796 @default.
• W2025363689 cites W2136591740 @default.
• W2025363689 cites W2138417516 @default.
• W2025363689 cites W2146197063 @default.
• W2025363689 cites W2160236349 @default.
• W2025363689 cites W2166438339 @default.
• W2025363689 cites W2169187183 @default.
• W2025363689 cites W2169529166 @default.
• W2025363689 cites W2183282212 @default.
• W2025363689 cites W4211063797 @default.
• W2025363689 doi "https://doi.org/10.1016/j.ydbio.2014.05.012" @default.
• W2025363689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24859262" @default.
• W2025363689 hasPublicationYear "2014" @default.
• W2025363689 type Work @default.
• W2025363689 sameAs 2025363689 @default.
• W2025363689 citedByCount "27" @default.
• W2025363689 countsByYear W20253636892015 @default.
• W2025363689 countsByYear W20253636892016 @default.
• W2025363689 countsByYear W20253636892017 @default.
• W2025363689 countsByYear W20253636892018 @default.
• W2025363689 countsByYear W20253636892019 @default.
• W2025363689 countsByYear W20253636892020 @default.
• W2025363689 countsByYear W20253636892021 @default.
• W2025363689 countsByYear W20253636892022 @default.
• W2025363689 countsByYear W20253636892023 @default.
• W2025363689 crossrefType "journal-article" @default.
• W2025363689 hasAuthorship W2025363689A5043041515 @default.
• W2025363689 hasAuthorship W2025363689A5046335803 @default.
• W2025363689 hasAuthorship W2025363689A5071838590 @default.
• W2025363689 hasAuthorship W2025363689A5076571566 @default.
• W2025363689 hasAuthorship W2025363689A5088573553 @default.
• W2025363689 hasAuthorship W2025363689A5090823805 @default.
• W2025363689 hasBestOaLocation W20253636891 @default.
• W2025363689 hasConcept C104317684 @default.
• W2025363689 hasConcept C121587040 @default.
• W2025363689 hasConcept C131364181 @default.
• W2025363689 hasConcept C148738053 @default.
• W2025363689 hasConcept C172680121 @default.
• W2025363689 hasConcept C173396325 @default.
• W2025363689 hasConcept C2776953305 @default.
• W2025363689 hasConcept C2777495146 @default.
• W2025363689 hasConcept C2777933648 @default.
• W2025363689 hasConcept C2779234561 @default.
• W2025363689 hasConcept C54355233 @default.
• W2025363689 hasConcept C81885089 @default.
• W2025363689 hasConcept C86339819 @default.
• W2025363689 hasConcept C86803240 @default.
• W2025363689 hasConcept C95444343 @default.
• W2025363689 hasConceptScore W2025363689C104317684 @default.
• W2025363689 hasConceptScore W2025363689C121587040 @default.
• W2025363689 hasConceptScore W2025363689C131364181 @default.
• W2025363689 hasConceptScore W2025363689C148738053 @default.
• W2025363689 hasConceptScore W2025363689C172680121 @default.
• W2025363689 hasConceptScore W2025363689C173396325 @default.
• W2025363689 hasConceptScore W2025363689C2776953305 @default.

• next