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- W2025367459 abstract "Purpose: We wanted to investigate the effect of nicergoline on corneal nerve regeneration in rat corneas after photorefractive keratectomy (PRK).Methods: Twenty Sprague–Dawley male rats were divided into two groups, the control group and the group that had been treated with nicergoline for 4 weeks. Corneal wound healing was evaluated by fluorescein staining after PRK. Immunofluorescent staining was performed in the rat corneas at 1 month after PRK with monoclonal antibodies for class III β-tubulin, calcitonin gene-related peptide (CGRP), and substance P (SP). The stained nerve areas were calculated using an image-analysis program.Results: The corneal wound healing rate was not significantly different between the nicergoline-treated rats and the control rats after PRK. At 1 month after PRK, the tubulin-positive, substance P-positive, and CGRP-positive nerve areas were significantly greater in the treatment group than those in the control group.Conclusion: Nicergoline treatment increased the corneal nerve area in the rats after they had undergone PRK. Nicergoline may help patients who have a decreased corneal sense, such as those with neurotrophic keratopathy and those patients after they undergo refractive surgery." @default.
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- W2025367459 date "2010-12-21" @default.
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- W2025367459 title "The Effects of Nicergoline on Corneal Nerve Regeneration in Rat Corneas after Photorefractive Keratectomy" @default.
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- W2025367459 doi "https://doi.org/10.3109/02713683.2010.528574" @default.
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