Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025368400> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2025368400 endingPage "106" @default.
- W2025368400 startingPage "103" @default.
- W2025368400 abstract "Group II metabotropic glutamate receptors (mGluRs) are distributed both pre- and postsynaptically in the striatum. By bilaterally administering a subgroup-selective agonist or antagonist into the dorsal striatum of chronically cannulated rats, this study examined the role of striatal group II mGluRs in the regulation of basal and dopamine-stimulated motor behavior. Intrastriatal injection of a group II agonist, (2S,2′R,3′R)-2-(2′,3′-dicarboxycyclopropyl)glycine (DCG-IV, 0.01, 0.1 and 1 nmol), dose-dependently reduced basal levels of motor activity. Pretreatment of rats with intrastriatal DCG-IV at a higher dose (1 nmol), but not a lower dose (0.01 nmol), produced complete or partial blockade of hyperlocomotion induced by acute injection of amphetamine (2.5 mg/kg, i.p.) or apomorphine (1 mg/kg, s.c.), respectively. Blockade of group II mGluRs by intrastriatal injection of a group II antagonist, (RS)-α-methylserine-O-phosphate monophenyl ester (10 nmol), was found to: (i) induce a moderate locomotion by itself; (ii) augment amphetamine-stimulated behaviors and (iii) attenuate DCG-IV-induced reduction of basal and amphetamine-stimulated motor activity. These data demonstrate that the group II mGluRs in the striatum play a significant role in the inhibitory modulation of tonic and phasic motor activity, which is most likely processed through both pre- and postsynaptic mechanisms." @default.
- W2025368400 created "2016-06-24" @default.
- W2025368400 creator A5049821571 @default.
- W2025368400 creator A5084182199 @default.
- W2025368400 date "1999-07-01" @default.
- W2025368400 modified "2023-10-16" @default.
- W2025368400 title "Protection against acute amphetamine-induced behavior by microinjection of a group II metabotropic glutamate receptor agonist into the dorsal striatum of rats" @default.
- W2025368400 cites W1756742701 @default.
- W2025368400 cites W1968616781 @default.
- W2025368400 cites W1974366641 @default.
- W2025368400 cites W1987209378 @default.
- W2025368400 cites W2009077347 @default.
- W2025368400 cites W2017406406 @default.
- W2025368400 cites W2023434269 @default.
- W2025368400 cites W2045628566 @default.
- W2025368400 cites W2054721393 @default.
- W2025368400 cites W2071466418 @default.
- W2025368400 cites W2075250244 @default.
- W2025368400 cites W2082049028 @default.
- W2025368400 cites W2085673544 @default.
- W2025368400 cites W2130227962 @default.
- W2025368400 cites W2140142911 @default.
- W2025368400 cites W2277185635 @default.
- W2025368400 doi "https://doi.org/10.1016/s0304-3940(99)00480-2" @default.
- W2025368400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10462108" @default.
- W2025368400 hasPublicationYear "1999" @default.
- W2025368400 type Work @default.
- W2025368400 sameAs 2025368400 @default.
- W2025368400 citedByCount "16" @default.
- W2025368400 countsByYear W20253684002016 @default.
- W2025368400 countsByYear W20253684002021 @default.
- W2025368400 crossrefType "journal-article" @default.
- W2025368400 hasAuthorship W2025368400A5049821571 @default.
- W2025368400 hasAuthorship W2025368400A5084182199 @default.
- W2025368400 hasConcept C126322002 @default.
- W2025368400 hasConcept C134018914 @default.
- W2025368400 hasConcept C170493617 @default.
- W2025368400 hasConcept C185592680 @default.
- W2025368400 hasConcept C26702167 @default.
- W2025368400 hasConcept C2777193897 @default.
- W2025368400 hasConcept C2778187257 @default.
- W2025368400 hasConcept C2778938600 @default.
- W2025368400 hasConcept C2780062018 @default.
- W2025368400 hasConcept C49051014 @default.
- W2025368400 hasConcept C513476851 @default.
- W2025368400 hasConcept C529278444 @default.
- W2025368400 hasConcept C71924100 @default.
- W2025368400 hasConcept C98274493 @default.
- W2025368400 hasConceptScore W2025368400C126322002 @default.
- W2025368400 hasConceptScore W2025368400C134018914 @default.
- W2025368400 hasConceptScore W2025368400C170493617 @default.
- W2025368400 hasConceptScore W2025368400C185592680 @default.
- W2025368400 hasConceptScore W2025368400C26702167 @default.
- W2025368400 hasConceptScore W2025368400C2777193897 @default.
- W2025368400 hasConceptScore W2025368400C2778187257 @default.
- W2025368400 hasConceptScore W2025368400C2778938600 @default.
- W2025368400 hasConceptScore W2025368400C2780062018 @default.
- W2025368400 hasConceptScore W2025368400C49051014 @default.
- W2025368400 hasConceptScore W2025368400C513476851 @default.
- W2025368400 hasConceptScore W2025368400C529278444 @default.
- W2025368400 hasConceptScore W2025368400C71924100 @default.
- W2025368400 hasConceptScore W2025368400C98274493 @default.
- W2025368400 hasIssue "2" @default.
- W2025368400 hasLocation W20253684001 @default.
- W2025368400 hasLocation W20253684002 @default.
- W2025368400 hasOpenAccess W2025368400 @default.
- W2025368400 hasPrimaryLocation W20253684001 @default.
- W2025368400 hasRelatedWork W1976047443 @default.
- W2025368400 hasRelatedWork W1976479858 @default.
- W2025368400 hasRelatedWork W1989327684 @default.
- W2025368400 hasRelatedWork W2004791753 @default.
- W2025368400 hasRelatedWork W2011759845 @default.
- W2025368400 hasRelatedWork W2039595001 @default.
- W2025368400 hasRelatedWork W2043311110 @default.
- W2025368400 hasRelatedWork W2071774239 @default.
- W2025368400 hasRelatedWork W2213641745 @default.
- W2025368400 hasRelatedWork W838010946 @default.
- W2025368400 hasVolume "270" @default.
- W2025368400 isParatext "false" @default.
- W2025368400 isRetracted "false" @default.
- W2025368400 magId "2025368400" @default.
- W2025368400 workType "article" @default.