Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025385351> ?p ?o ?g. }
- W2025385351 endingPage "280" @default.
- W2025385351 startingPage "265" @default.
- W2025385351 abstract "To review the safety of biologic agents used to treat rheumatoid arthritis (RA) and other autoimmune diseases, with a focus on rituximab.Information was gathered from a search of the PubMed database and from major congress abstract listings through June 2007.Rituximab is approved for treating RA in patients with an inadequate response to TNF inhibitors and is under study in other indications for RA and other autoimmune disorders. The current safety profile of rituximab in RA is known from Phase II and III studies conducted preapproval, treating approximately 750 patients, as well as from long-term extension studies with repeated therapy. Clinical trials have established that the most common adverse events are infusion-associated reactions, seen in 29 to 40% of patients, most of which are mild to moderate and occur following the first rituximab infusion, with incidence and severity decreasing with subsequent infusions. Rates of infections and serious infections to date are within the range expected for RA patients treated with other biologic agents, but the longer term effects of B-cell depletion and the effects of repeated treatment on the risk of infections are uncertain. Information is limited for rituximab safety in other autoimmune disorders but current data do not suggest that there is a significant difference in adverse events from that previously reported.Rituximab is an important addition to the rheumatologist's armamentarium for the treatment of difficult RA and ongoing trials will determine its utility in other indications for RA and other autoimmune conditions. The true safety profile of rituximab will emerge as larger numbers of patients are treated in routine clinical practice." @default.
- W2025385351 created "2016-06-24" @default.
- W2025385351 creator A5046261111 @default.
- W2025385351 date "2009-02-01" @default.
- W2025385351 modified "2023-10-17" @default.
- W2025385351 title "Safety of Biologic Therapy in Rheumatoid Arthritis and Other Autoimmune Diseases: Focus on Rituximab" @default.
- W2025385351 cites W1551505131 @default.
- W2025385351 cites W1915689252 @default.
- W2025385351 cites W1963970819 @default.
- W2025385351 cites W1967429097 @default.
- W2025385351 cites W1970551142 @default.
- W2025385351 cites W1975338840 @default.
- W2025385351 cites W1980534680 @default.
- W2025385351 cites W1981535363 @default.
- W2025385351 cites W1981933562 @default.
- W2025385351 cites W1988848155 @default.
- W2025385351 cites W1990393482 @default.
- W2025385351 cites W1991403822 @default.
- W2025385351 cites W1994065448 @default.
- W2025385351 cites W1998618256 @default.
- W2025385351 cites W1999962477 @default.
- W2025385351 cites W2007252822 @default.
- W2025385351 cites W2008131591 @default.
- W2025385351 cites W2010675961 @default.
- W2025385351 cites W2011557149 @default.
- W2025385351 cites W2016963118 @default.
- W2025385351 cites W2020337063 @default.
- W2025385351 cites W2021830136 @default.
- W2025385351 cites W2023473273 @default.
- W2025385351 cites W2024235155 @default.
- W2025385351 cites W2024644107 @default.
- W2025385351 cites W2025775448 @default.
- W2025385351 cites W2028453745 @default.
- W2025385351 cites W2029993898 @default.
- W2025385351 cites W2039207296 @default.
- W2025385351 cites W2044788893 @default.
- W2025385351 cites W2046900942 @default.
- W2025385351 cites W2051022408 @default.
- W2025385351 cites W2051649686 @default.
- W2025385351 cites W2052970048 @default.
- W2025385351 cites W2055235937 @default.
- W2025385351 cites W2057194530 @default.
- W2025385351 cites W2057425338 @default.
- W2025385351 cites W2058605959 @default.
- W2025385351 cites W2064739203 @default.
- W2025385351 cites W2072882391 @default.
- W2025385351 cites W2073170925 @default.
- W2025385351 cites W2073743940 @default.
- W2025385351 cites W2075632612 @default.
- W2025385351 cites W2077158310 @default.
- W2025385351 cites W2077286174 @default.
- W2025385351 cites W2080506899 @default.
- W2025385351 cites W2084718852 @default.
- W2025385351 cites W2084935104 @default.
- W2025385351 cites W2085242627 @default.
- W2025385351 cites W2089016290 @default.
- W2025385351 cites W2097564087 @default.
- W2025385351 cites W2097998028 @default.
- W2025385351 cites W2100974168 @default.
- W2025385351 cites W2102133319 @default.
- W2025385351 cites W2107381832 @default.
- W2025385351 cites W2108102227 @default.
- W2025385351 cites W2116974590 @default.
- W2025385351 cites W2118994799 @default.
- W2025385351 cites W2120574509 @default.
- W2025385351 cites W2121621997 @default.
- W2025385351 cites W2122507029 @default.
- W2025385351 cites W2124670599 @default.
- W2025385351 cites W2126641568 @default.
- W2025385351 cites W2126746651 @default.
- W2025385351 cites W2127258004 @default.
- W2025385351 cites W2131817768 @default.
- W2025385351 cites W2143812550 @default.
- W2025385351 cites W2144047233 @default.
- W2025385351 cites W2144937046 @default.
- W2025385351 cites W2148920525 @default.
- W2025385351 cites W2154059578 @default.
- W2025385351 cites W2155273246 @default.
- W2025385351 cites W2156140442 @default.
- W2025385351 cites W2159197023 @default.
- W2025385351 cites W2162254515 @default.
- W2025385351 cites W2167404036 @default.
- W2025385351 cites W2168711492 @default.
- W2025385351 cites W2319957449 @default.
- W2025385351 cites W334564628 @default.
- W2025385351 cites W4235975451 @default.
- W2025385351 cites W4361867558 @default.
- W2025385351 doi "https://doi.org/10.1016/j.semarthrit.2008.01.001" @default.
- W2025385351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18336874" @default.
- W2025385351 hasPublicationYear "2009" @default.
- W2025385351 type Work @default.
- W2025385351 sameAs 2025385351 @default.
- W2025385351 citedByCount "58" @default.
- W2025385351 countsByYear W20253853512012 @default.
- W2025385351 countsByYear W20253853512013 @default.
- W2025385351 countsByYear W20253853512014 @default.
- W2025385351 countsByYear W20253853512015 @default.
- W2025385351 countsByYear W20253853512016 @default.