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- W2025391298 abstract "Despite the critical role tendons play in transmitting loads throughout the musculoskeletal system, little is known about the microstructural mechanisms underlying their mechanical function. Of particular interest is whether collagen fibrils in tendon fascicles bear load independently or if load is transferred between fibrils through interfibrillar shear forces. We conducted multiscale experimental testing and developed a microstructural shear lag model to explicitly test whether interfibrillar shear load transfer is indeed the fibrillar loading mechanism in tendon. Experimental correlations between fascicle macroscale mechanics and microscale interfibrillar sliding suggest that fibrils are discontinuous and share load. Moreover, for the first time, we demonstrate that a shear lag model can replicate the fascicle macroscale mechanics as well as predict the microscale fibrillar deformations. Since interfibrillar shear stress is the fundamental loading mechanism assumed in the model, this result provides strong evidence that load is transferred between fibrils in tendon and possibly other aligned collagenous tissues. Conclusively establishing this fibrillar loading mechanism and identifying the involved structural components should help develop repair strategies for tissue degeneration and guide the design of tissue engineered replacements." @default.
- W2025391298 created "2016-06-24" @default.
- W2025391298 creator A5015297374 @default.
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- W2025391298 date "2014-06-01" @default.
- W2025391298 modified "2023-10-16" @default.
- W2025391298 title "Interfibrillar shear stress is the loading mechanism of collagen fibrils in tendon" @default.
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- W2025391298 doi "https://doi.org/10.1016/j.actbio.2014.01.032" @default.
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