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- W2025395004 abstract "The aim of this study was to prove the hypothesis that exocrine pancreatic function determines resting energy expenditure (REE) in Cystic Fibrosis (CF). Thirty-eight CF individuals (9 to 34, 19.98±1.0 yrs) were divided in two groups: 32 patients, who had exocrine pancreatic insufficiency (PI) (Group A) and 6 patients with pancreatic sufficiency (PS) (Group B). A sub-group C included 19 PI patients whose predicted FEV1% was comparable to that of Group B. Indirect calorimetry and Schofield equations were applied to calculate predicted REE. Measured REE was expressed as % of the predicted values. BMI and BMI z-scores were related to REE. The results were expressed as mean±standard error. Group A had increased REE% (113±3.81%) as opposed to group B whose REE% was similar to the predicted values (98.9±3.81%) (p 0.022). Sub-group C also had increased REE% (110.82±2.72%), which was comparable to that of group A and significantly different from group B (p 0.035). Mean FEV1% was 74.53±4.9%, 86.33±10.1% 92.1±4.55%, mean BMI was 19.7±0.5, 25.6±2.06 and 19.13±0.66 and BMI z-scores were 0.72±0.2, 0.75±0.51 and 0.62±0.26, in Group A, B and C, respectively. Significant correlation was demonstrated between REE% and BMI z-scores in-group B (r 0.83, p 0.038) but not in groups A and C. Conclusions: Clinically stable CF patients with similar pulmonary function exhibited increased REE% only in the presence of exocrine pancreatic insufficiency. Pancreatic sufficiency was related to normal REE%. Furthermore, REE% strongly correlated with BMI z-scores in pancreatic sufficiency but not in pancreatic insufficiency. These findings support the hypothesis that exocrine pancreatic rather than pulmonary function may determine nutritional status and REE% in CF patients. 6. Gastroenterology" @default.
- W2025395004 created "2016-06-24" @default.
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- W2025395004 date "2006-01-01" @default.
- W2025395004 modified "2023-09-26" @default.
- W2025395004 title "240 Exocrine pancreatic function and resting energy expenditure in Cystic Fibrosis" @default.
- W2025395004 doi "https://doi.org/10.1016/s1569-1993(06)80217-1" @default.
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