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• W2025408537 startingPage "e45087" @default.
• W2025408537 abstract "Long chain acyl-CoA synthetases are essential enzymes of lipid metabolism, and have also been implicated in the cellular uptake of fatty acids. It is controversial if some or all of these enzymes have an additional function as fatty acid transporters at the plasma membrane. The most abundant acyl-CoA synthetases in adipocytes are FATP1, ACSVL4/FATP4 and ACSL1. Previous studies have suggested that they increase fatty acid uptake by direct transport across the plasma membrane. Here, we used a gain-of-function approach and established FATP1, ACSVL4/FATP4 and ACSL1 stably expressing 3T3-L1 adipocytes by retroviral transduction. All overexpressing cell lines showed increased acyl-CoA synthetase activity and fatty acid uptake. FATP1 and ACSVL4/FATP4 localized to the endoplasmic reticulum by confocal microscopy and subcellular fractionation whereas ACSL1 was found on mitochondria. Insulin increased fatty acid uptake but without changing the localization of FATP1 or ACSVL4/FATP4. We conclude that overexpressed acyl-CoA synthetases are able to facilitate fatty acid uptake in 3T3-L1 adipocytes. The intracellular localization of FATP1, ACSVL4/FATP4 and ACSL1 indicates that this is an indirect effect. We suggest that metabolic trapping is the mechanism behind the influence of acyl-CoA synthetases on cellular fatty acid uptake." @default.
• W2025408537 created "2016-06-24" @default.
• W2025408537 creator A5013210540 @default.
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• W2025408537 date "2012-09-14" @default.
• W2025408537 modified "2023-10-03" @default.
• W2025408537 title "Overexpressed FATP1, ACSVL4/FATP4 and ACSL1 Increase the Cellular Fatty Acid Uptake of 3T3-L1 Adipocytes but Are Localized on Intracellular Membranes" @default.
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• W2025408537 doi "https://doi.org/10.1371/journal.pone.0045087" @default.
• W2025408537 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3443241" @default.
• W2025408537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23024797" @default.
• W2025408537 hasPublicationYear "2012" @default.
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