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• W2025415097 abstract "HomeCirculation: Cardiovascular GeneticsVol. 4, No. 1Response to Letter Regarding Article, “Circulating MicroRNA-208b and MicroRNA-499 Reflect Myocardial Damage in Cardiovascular Disease” Free AccessReplyPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessReplyPDF/EPUBResponse to Letter Regarding Article, “Circulating MicroRNA-208b and MicroRNA-499 Reflect Myocardial Damage in Cardiovascular Disease” Maarten F. Corsten, Robert Dennert and Sylvia Jochems Tatiana Kuznetsova Yvan Devaux L. Hofstra Daniel R. Wagner Jan A. Staessen Stephane Heymans and Blanche Schroen Maarten F. CorstenMaarten F. Corsten Search for more papers by this author , Robert DennertRobert Dennert Search for more papers by this author and Sylvia JochemsSylvia Jochems Search for more papers by this author Tatiana KuznetsovaTatiana Kuznetsova Search for more papers by this author Yvan DevauxYvan Devaux Search for more papers by this author L. HofstraL. Hofstra Search for more papers by this author Daniel R. WagnerDaniel R. Wagner Search for more papers by this author Jan A. StaessenJan A. Staessen Search for more papers by this author Stephane HeymansStephane Heymans Search for more papers by this author and Blanche SchroenBlanche Schroen Search for more papers by this author Originally published1 Feb 2011https://doi.org/10.1161/CIRCGENETICS.110.958959Circulation: Cardiovascular Genetics. 2011;4:e8The stability and detectability of circulating microRNAs in human plasma provides exciting opportunities for the use of microRNAs as biomarkers for human disease. In an exploratory study, we have investigated the behavior of selected microRNAs, including the cardiac-enriched microRNAs −208b and −499 in a panel of cardiovascular diseases and found a striking elevation of the latter 2 microRNAs in plasmas of patients with acute myocardial infarction.1Multiple groups have published concordant findings about the diagnostic accuracy of both microRNAs in the setting of acute myocardial infarction.2,3 However, differences in isolation efficiency have led reports on microRNA-208b levels—which are typically around the detection limit—to be more variable than levels of the more abundant microRNA-499. We therefore share the correspondents' enthusiasm for microRNA-499 as a potential biomarker for acute myocardial infarction. Importantly, clinical relevance of such biomarkers will depend on the development of rapid and sensitive detection methods for plasma microRNA, as the Achilles' heel of troponin testing (clinical chemistry's gold standard for myocardial damage) lies in its limited sensitivity during the first hours after onset of pain.In addition, we agree that standardized normalization methods are a prerequisite for universal applicability of plasma microRNAs as biomarkers. Normalization using spiked-in synthetic oligonucleotides accurately corrects for confounders in RNA isolation, reverse transcription, and real-time polymerase chain reaction measurements. Alternatively, normalization using endogenous “stable” microRNAs should theoretically also correct for RNA stability during sample generation and storage (although no effect of prolonged storage at −80°C could be observed in our study). Unfortunately, there is no consensus regarding stable microRNAs for correction. The initially popular reference miR-164 was reported not to be reproducible by others.5 In practice, many studies use microRNAs that appear stable in their own arrays, and those are typically different per study. Thus, in our opinion, spike normalization represents the method of choice until genuinely stable plasma microRNAs are identified.Data from us and other investigators open the exciting path to the clinical application of microRNA diagnostics. It seems a matter of time before a reliable diagnostic kit remedies the currently limiting issues of variable sensitivity, normalization, and detection pace.Maarten F. Corsten, MDRobert Dennert, MDSylvia Jochems, BSc Center for Heart Failure Research Cardiovascular Research Institute Maastricht Maastricht, The NetherlandsTatiana Kuznetsova, MD, PhD Division of Hypertension and Cardiovascular Rehabilitation Department of Cardiovascular Diseases University of Leuven Leuven, BelgiumYvan Devaux, PhD Centre de Recherche Public Santé LuxembourgL. Hofstra, MD, PhD Maastricht University Medical Center Maastricht, The NetherlandsDaniel R. Wagner, MD, PhD Centre de Recherche Public Santé Centre Hospitalier Luxembourg LuxembourgJan A. Staessen, MD, PhD Division of Hypertension and Cardiovascular Rehabilitation Department of Cardiovascular Diseases University of Leuven Leuven, Belgium Department of Epidemiology Maastricht University Maastricht, The NetherlandsStephane Heymans, MD, PhDBlanche Schroen, PhD Center for Heart Failure Research Cardiovascular Research Institute Maastricht Maastricht, The NetherlandsDisclosuresNone.References1. Corsten MF, Dennert R, Jochems S, Kuznetsova T, Devaux Y, Hofstra L, Wagner DR, Staessen J, Heymans S, Schroen B. Circulating microRNA-208b and microRNA-499 reflect myocardial damage in cardiovascular disease. Circ Cardiovasc Genet. 2010; 3:499–506.LinkGoogle Scholar2. Adachi T, Nakanishi M, Otsuka Y, Nishimura K, Hirokawa G, Goto Y, Nonogi H, Iwai N. Plasma MicroRNA 499 as a biomarker of acute myocardial infarction. Clin Chem. 2010; 56:1183–1185.CrossrefMedlineGoogle Scholar3. Wang GK, Zhu JQ, Zhang JT, Li Q, Li Y, He J, Qin YW, Jing Q. Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur Heart J. 2010; 31:659–666.CrossrefMedlineGoogle Scholar4. Lawrie CH, Gal S, Dunlop HM, Pushkaran B, Liggins AP, Pulford K, Banham AH, Pezzella F, Boultwood J, Wainscoat JS, Hatton CS, Harris AL. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br J Haematol. 2008; 141:672–675.CrossrefMedlineGoogle Scholar5. Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K, Guo J, Zhang Y, Chen J, Guo X, Li Q, Li X, Wang W, Wang J, Jiang X, Xiang Y, Xu C, Zheng P, Zhang J, Li R, Zhang H, Shang X, Gong T, Ning G, Zen K, Zhang CY. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 2008; 18:997–1006.CrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsCited By Ionescu R and Cretoiu S (2021) MicroRNAs as monitoring markers for right-sided heart failure and congestive hepatopathy, Journal of Medicine and Life, 10.25122/jml-2021-0071, 14:2, (142-147) (2012) Current World Literature, Current Opinion in Cardiology, 10.1097/HCO.0b013e328352dfaf, 27:3, (318-326), Online publication date: 1-May-2012. February 2011Vol 4, Issue 1 Advertisement Article InformationMetrics © 2011 American Heart Association, Inc.https://doi.org/10.1161/CIRCGENETICS.110.958959 Originally publishedFebruary 1, 2011 PDF download Advertisement SubjectsDiagnostic Testing" @default.
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