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• W2025419786 abstract "Piwi proteins, together with their bound Piwi-interacting RNAs, constitute an evolutionarily conserved, germline-specific innate immune system. The piRNA pathway is one of the key mechanisms for silencing transposable elements in the germline, thereby preserving genome integrity between generations. Recent work from several groups has significantly advanced our understanding of how piRNAs arise from discrete genomic loci, termed piRNA clusters, and how these Piwi-piRNA complexes enforce transposon silencing. Here, we discuss these recent findings, as well as highlight some aspects of piRNA biology that continue to escape our understanding." @default.
• W2025419786 created "2016-06-24" @default.
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• W2025419786 date "2013-02-01" @default.
• W2025419786 modified "2023-09-27" @default.
• W2025419786 title "The piRNA pathway in flies: highlights and future directions" @default.
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• W2025419786 doi "https://doi.org/10.1016/j.gde.2012.12.003" @default.
• W2025419786 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3621807" @default.
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