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- W2025427424 abstract "Excitotoxicity (the toxic overstimulation of neurons by the excitatory transmitter Glutamate) is a central process in widespread neurodegenerative conditions such as brain ischemia and chronic neurological diseases. Many mechanisms have been suggested to mediate excitotoxicity, but their significance across diverse excitotoxic scenarios remains unclear. Death Associated Protein Kinase (DAPK), a critical molecular switch that controls a range of key signaling and cell death pathways, has been suggested to have an important role in excitotoxicity. However, the molecular mechanism by which DAPK exerts its effect is controversial. A few distinct mechanisms have been suggested by single (sometimes contradicting) studies, and a larger array of potential mechanisms is implicated by the extensive interactome of DAPK. Here we analyze a well-characterized model of excitotoxicity in the nematode C. elegans to show that DAPK is an important mediator of excitotoxic neurodegeneration across a large evolutionary distance. We further show that some proposed mechanisms of DAPK’s action (modulation of synaptic strength, involvement of the DANGER-related protein MAB-21, and autophagy) do not have a major role in nematode excitotoxicity. In contrast, Pin1/PINN-1 (a DAPK interaction-partner and a peptidyl-prolyl isomerase involved in chronic neurodegenerative conditions) suppresses neurodegeneration in our excitotoxicity model. Our studies highlight the prominence of DAPK and Pin1/PINN-1 as conserved mediators of cell death processes in diverse scenarios of neurodegeneration." @default.
- W2025427424 created "2016-06-24" @default.
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- W2025427424 date "2015-04-23" @default.
- W2025427424 modified "2023-10-18" @default.
- W2025427424 title "Death Associated Protein Kinase (DAPK) -mediated neurodegenerative mechanisms in nematode excitotoxicity" @default.
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- W2025427424 cites W1533853049 @default.
- W2025427424 cites W1586783369 @default.
- W2025427424 cites W1964017923 @default.
- W2025427424 cites W1965218644 @default.
- W2025427424 cites W1966556202 @default.
- W2025427424 cites W1967277826 @default.
- W2025427424 cites W1969758781 @default.
- W2025427424 cites W1971252951 @default.
- W2025427424 cites W1972764026 @default.
- W2025427424 cites W1974036368 @default.
- W2025427424 cites W1980744062 @default.
- W2025427424 cites W1985028337 @default.
- W2025427424 cites W1986535773 @default.
- W2025427424 cites W1986547465 @default.
- W2025427424 cites W1990286087 @default.
- W2025427424 cites W1991075835 @default.
- W2025427424 cites W1991211989 @default.
- W2025427424 cites W1992177920 @default.
- W2025427424 cites W1994239968 @default.
- W2025427424 cites W1994576130 @default.
- W2025427424 cites W1997333958 @default.
- W2025427424 cites W1999083701 @default.
- W2025427424 cites W2002664835 @default.
- W2025427424 cites W2007526154 @default.
- W2025427424 cites W2024380057 @default.
- W2025427424 cites W2024790646 @default.
- W2025427424 cites W2028279469 @default.
- W2025427424 cites W2030978330 @default.
- W2025427424 cites W2031588422 @default.
- W2025427424 cites W2031837904 @default.
- W2025427424 cites W2034132952 @default.
- W2025427424 cites W2036187541 @default.
- W2025427424 cites W2037852973 @default.
- W2025427424 cites W2041352318 @default.
- W2025427424 cites W2041532203 @default.
- W2025427424 cites W2042550512 @default.
- W2025427424 cites W2046250764 @default.
- W2025427424 cites W2047509412 @default.
- W2025427424 cites W2048030072 @default.
- W2025427424 cites W2049669494 @default.
- W2025427424 cites W2052113027 @default.
- W2025427424 cites W2053875448 @default.
- W2025427424 cites W2058615553 @default.
- W2025427424 cites W2059309243 @default.
- W2025427424 cites W2060384627 @default.
- W2025427424 cites W2062371417 @default.
- W2025427424 cites W2063541896 @default.
- W2025427424 cites W2074263866 @default.
- W2025427424 cites W2079836926 @default.
- W2025427424 cites W2080659767 @default.
- W2025427424 cites W2082914711 @default.
- W2025427424 cites W2083004303 @default.
- W2025427424 cites W2084796940 @default.
- W2025427424 cites W2085184384 @default.
- W2025427424 cites W2086751197 @default.
- W2025427424 cites W2092990950 @default.
- W2025427424 cites W2095001952 @default.
- W2025427424 cites W2097293665 @default.
- W2025427424 cites W2098868575 @default.
- W2025427424 cites W2106622563 @default.
- W2025427424 cites W2109034822 @default.
- W2025427424 cites W2112215250 @default.
- W2025427424 cites W2113636792 @default.
- W2025427424 cites W2114266271 @default.
- W2025427424 cites W2120002749 @default.
- W2025427424 cites W2120290958 @default.
- W2025427424 cites W2124157069 @default.
- W2025427424 cites W2125402857 @default.
- W2025427424 cites W2125795242 @default.
- W2025427424 cites W2145965027 @default.
- W2025427424 cites W2147045345 @default.
- W2025427424 cites W2154100802 @default.
- W2025427424 cites W2160845673 @default.
- W2025427424 cites W2164590669 @default.
- W2025427424 cites W2166878794 @default.
- W2025427424 cites W2170076805 @default.
- W2025427424 cites W2171128065 @default.
- W2025427424 cites W4210979710 @default.
- W2025427424 cites W5736281 @default.
- W2025427424 doi "https://doi.org/10.1186/s12868-015-0158-2" @default.
- W2025427424 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4414438" @default.
- W2025427424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25899010" @default.