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- W2025433914 abstract "Summary: Today, positron emission tomography (PET) investigation using fluorodeoxyglucose (FDG) is the most sensitive and specific single modality established for localizing metastases of medullary thyroid cancer (MTC). Even at calcitonin serum levels below 20 pg/ml, tumour localization may be successful in individual cases. However, especially in such early tumour stages, the morphological correlation using PET is unsatisfactory. With the newly available fixed combination of PET and computed tomography (PET/CT), this drawback can be overcome as PET/CT allows a point-by-point correlation of pathological function with morphological structure. Conventional PET alone yielded an approx 80 % sensitivity and specificity in MTC: a result that will be surpassed by the combined PET/CT scanner. Zusammenfassung: Derzeit stellt die PET-Untersuchung mit FDG von den etablierten Verfahren die sensitivste und spezifischste Einzeluntersuchung zur Lokalisation von Metastasen des medullären Schilddrüsenkarzinoms dar. Selbst bei einer Calcitoninserumkonzentration von unter 20 pg/ml kann im Einzelfall die Lokalisation gelingen. Allerdings ist die morphologische Information insbesondere bei solchen Frühstadien mit der PET unbefriedigend. Mittels der jetzt verfügbaren festen Kombination eines PET und eines CT (PET/CT) kann dieser Nachteil überwunden werden, da die PET/CT eine punktgenaue Zuordnung der pathologischen Funktion zu einer morphologischen Struktur erlaubt. Die bereits mit der konventionellen PET beim MTC erzielten Sensitivitäten und Spezifitäten von ca. 80 % dürften mit dem kombinierten PET/CT Scanner noch überboten werden." @default.
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- W2025433914 date "2003-02-01" @default.
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- W2025433914 title "Diagnosis in Medullary Thyroid Cancer with [18F]FDG-PET and Improvement Using a Combined PET/CT Scanner" @default.
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- W2025433914 doi "https://doi.org/10.1046/j.1563-2571.2003.02045.x" @default.
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