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- W2025434572 abstract "No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Mar 2002RABBIT MUSCLE AND URETHRAL IN SITU BIOCOMPATIBILITY PROPERTIES OF THE SELF-REINFORCED L-LACTIDE-GLYCOLIC ACID COPOLYMER 80: 20 SPIRAL STENT SUSANNA LAAKSOVIRTA, MARITA LAURILA, TAINA ISOTALO, TERO VÄLIMAA, TEUVO L.J. TAMMELA, PERTTI TÖRMÄLÄ, and MARTTI TALJA SUSANNA LAAKSOVIRTASUSANNA LAAKSOVIRTA More articles by this author , MARITA LAURILAMARITA LAURILA More articles by this author , TAINA ISOTALOTAINA ISOTALO More articles by this author , TERO VÄLIMAATERO VÄLIMAA More articles by this author , TEUVO L.J. TAMMELATEUVO L.J. TAMMELA More articles by this author , PERTTI TÖRMÄLÄPERTTI TÖRMÄLÄ More articles by this author , and MARTTI TALJAMARTTI TALJA More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)65357-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: A new type of self-reinforced L-lactide-glycolic acid copolymer, molar ratio 80:20, stent was developed. We evaluated the tissue biocompatibility properties of the new material. Materials and Methods: Rods made of self-reinforced L-lactide-glycolic acid copolymer were inserted into rabbit dorsal muscles and rods of latex or polyvinylchloride and silicone served as positive and negative controls, respectively. Urethral stents of self-reinforced L-lactide-glycolic acid copolymer and steel were inserted in situ via cystoscopy into the rabbit prostatic urethra. The animals were sacrificed after 2 weeks, 1, 2 and 3 months, respectively. In situ histological analysis was done. Tissue reactions around the implantation types were analyzed histologically and scored semiquantitatively. In addition, macroscopic analysis was done of the urethral in situ stents. Results: In rabbit muscle implantation test tissue reaction to the self-reinforced L-lactide-glycolic acid copolymer stent resembled that of negative control silicone. Less than moderate chronic inflammatory changes gradually subsided after 2 weeks. Foreign materials in the tissue and the reaction to these materials began to disappear after 1 month and at 3 months were completely absent. All rabbits fitted with the stent voided normally postoperatively. Self-reinforced L-lactide-glycolic acid copolymer stents were soft, partially fragmented and easily disintegrated when touched at 2 months, and were almost completely degraded at 3 months. The material did not encroach into the urethral wall macroscopically or microscopically. No calcification on the self-reinforced L-lactide-glycolic acid copolymer stents or bladder stone formation was seen. Conclusions: The new self-reinforced L-lactide-glycolic acid copolymer 80:20 material is safe, highly biocompatible and suited for future clinical use. It is most appropriate for preventing postoperative urinary retention after most minimally invasive thermal treatments for benign prostatic hyperplasia. References 1 : Der intraprostatische “partiell Katheter” (urologische Spirale).. Urologe1980; 19: 236. Google Scholar 2 : A new treatment for urethral strictures. Lancet1988; 1: 424. Google Scholar 3 : The intraprostatic spiral: a new device for insertion with the patient under local anesthesia and with ultrasonic guidance with 3 months of follow-up. J Urol1989; 142: 756. Abstract, Google Scholar 4 : The titanium intraprostatic stent: the United States experience. 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Link, Google Scholar From the Department of Urology, Tampere University Hospital and Medical School and Department of Pathology, University of Tampere, Department of Surgery, Päijät-Häme Central Hospital and Institute of Biomaterials, Tampere University of Technology, Tampere, Finland© 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byBEIKO D, KNUDSEN B, WATTERSON J, CADIEUX P, REID G and DENSTEDT J (2018) URINARY TRACT BIOMATERIALSJournal of Urology, VOL. 171, NO. 6 Part 1, (2438-2444), Online publication date: 1-Jun-2004.VAAJANEN A, NUUTINEN J, ISOTALO T, TÖRMÄLÄ P, TAMMELA T and TALJA M (2018) Expansion and Fixation Properties of a New Braided Biodegradable Urethral Stent: An Experimental Study in the RabbitJournal of Urology, VOL. 169, NO. 3, (1171-1174), Online publication date: 1-Mar-2003. Volume 167Issue 3March 2002Page: 1527-1531 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.Keywordsstentsrabbitsbiocompatible materialsureterMetricsAuthor Information SUSANNA LAAKSOVIRTA More articles by this author MARITA LAURILA More articles by this author TAINA ISOTALO More articles by this author TERO VÄLIMAA More articles by this author TEUVO L.J. TAMMELA More articles by this author PERTTI TÖRMÄLÄ More articles by this author MARTTI TALJA More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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- W2025434572 title "RABBIT MUSCLE AND URETHRAL IN SITU BIOCOMPATIBILITY PROPERTIES OF THE SELF-REINFORCED L-LACTIDE-GLYCOLIC ACID COPOLYMER 80: 20 SPIRAL STENT" @default.
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