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- W2025439904 abstract "Osteoporosis has been consistently reported in patients who have undergone solid-organ transplantation, such as kidney, heart, and liver. These patients have a striking increase in risk of vertebral and non-vertebral fractures. 1 Ramsey-Goldman R Dunn JE Dunlop DD et al. Increased risk of fracture in patients receiving solid organ transplants. J Bone Miner Res. 1999; 14: 456-463 Crossref PubMed Scopus (227) Google Scholar During the year after cardiac or liver transplantation, 20–50% of patients have fractures, and longitudinal studies indicate that most of these fractures occur after the operation. 2 Shane E Rivas M Staron RB et al. Fracture after cardiac transplantation: A prospective longitudinal study. J Clin Endocrinol Metab. 1996; 81: 1740-1746 Crossref PubMed Scopus (156) Google Scholar , 3 Meys E Fontanges F Fourcade N Thomasson A Pouyet M Delmas PD Bone loss after orthotopic liver transplantation. Am J Med. 1994; 97: 445-450 Summary Full Text PDF PubMed Scopus (160) Google Scholar , Most are vertebral fractures, which occur more commonly in women than in men. The rate of bone loss accelerates in the first year after cardiac and liver transplantations, then stabilises or declines at the lumbar spine, but at skeletal sites made of cortical bone such as the hip the acceleration continues for the next few years. In view of the morbidity and mortality associated with hip and vertebral fractures, such a pattern will influence the quality of life of these patients. Frequency and predictors of osteoporotic fractures after cardiac or liver transplantation: a follow-up studyThe high frequency of osteoporotic fractures in the 2 years after transplantation and the limitations of reliable fracture-risk predictions, show the need to investigate preventive therapies. Full-Text PDF" @default.
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- W2025439904 date "2001-02-01" @default.
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- W2025439904 title "Osteoporosis in patients with organ transplants: a neglected problem" @default.
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- W2025439904 doi "https://doi.org/10.1016/s0140-6736(00)03632-1" @default.
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