FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025446117> ?p ?o ?g. }

• W2025446117 endingPage "129" @default.
• W2025446117 startingPage "121" @default.
• W2025446117 abstract "Symptomatic hyperlactataemia and lactic acidosis (SHLA) are potentially life-threatening complications associated with stavudine (d4T), an antiretroviral therapy (ART) drug widely used in developing countries.Cases comprised all symptomatic patients with measured lactates >or= 5 mmol/L referred to a South African hospital between August 2003 and November 2005. Matched controls were selected according to facility and duration on ART.Seventy-one cases and 142 controls were included in the study. The majority of cases presented between 6 and 18 months on ART. Female sex [adjusted odds ratio (AOR) 23.4; 95% confidence interval (CI) 4.0-136.6], a baseline weight between 60 and 75 kg (AOR 4.5; 95% CI 1.4-14.1) or, in particular, >or= 75 kg (AOR 19.4; 95% CI 4.1-82.5) at ART initiation and gaining >or= 6 kg in the first 3 months on therapy (AOR 3.5; 95% CI 1.3-9.5) were independent risk factors identifying patients who may subsequently develop SHLA. Weight loss of >or= 2 kg (AOR 6.1; 95% CI 2.0-18.3), a rise in alanine aminotransferase (ALT) >or= 10 U/L (AOR 3.1; 95% CI 1.1-8.9), the presence of at least one of three major symptoms (vomiting, nausea and abdominal pains) of SHLA (AOR 12.6; 95% CI 3.3-47.2) and peripheral neuropathy (AOR 3.4; 95% CI 1.1-9.8) were the clinical parameters that were most able to identify patients with early manifestations of SHLA.This is the first case-control study for SHLA in Southern Africa. Given these findings, we advise that stavudine is avoided in overweight women. Weight loss, a rise in ALT, peripheral neuropathy and/or gastrointestinal symptoms should prompt healthcare workers to assess for SHLA, especially at between 6 and 18 months on ART." @default.
• W2025446117 created "2016-06-24" @default.
• W2025446117 creator A5009435222 @default.
• W2025446117 creator A5022282042 @default.
• W2025446117 creator A5035633161 @default.
• W2025446117 creator A5044686047 @default.
• W2025446117 creator A5051693361 @default.
• W2025446117 date "2010-02-01" @default.
• W2025446117 modified "2023-09-26" @default.
• W2025446117 title "Risk factors for and clinical characteristics of severe hyperlactataemia in patients receiving antiretroviral therapy: a case–control study" @default.
• W2025446117 cites W1990871698 @default.
• W2025446117 cites W1991858260 @default.
• W2025446117 cites W2010199010 @default.
• W2025446117 cites W2036318078 @default.
• W2025446117 cites W2057511215 @default.
• W2025446117 cites W2065313630 @default.
• W2025446117 cites W2070677270 @default.
• W2025446117 cites W2079921830 @default.
• W2025446117 cites W2080049833 @default.
• W2025446117 cites W2084681121 @default.
• W2025446117 cites W2085653450 @default.
• W2025446117 cites W2093762250 @default.
• W2025446117 cites W2099550290 @default.
• W2025446117 cites W2099914228 @default.
• W2025446117 cites W2103671556 @default.
• W2025446117 cites W2104749679 @default.
• W2025446117 cites W2107267410 @default.
• W2025446117 cites W2109922627 @default.
• W2025446117 cites W2117659981 @default.
• W2025446117 cites W2121641482 @default.
• W2025446117 cites W2132891719 @default.
• W2025446117 cites W2133166320 @default.
• W2025446117 cites W2149194223 @default.
• W2025446117 cites W2158809828 @default.
• W2025446117 cites W2161785129 @default.
• W2025446117 cites W2166210336 @default.
• W2025446117 cites W566937086 @default.
• W2025446117 doi "https://doi.org/10.1111/j.1468-1293.2009.00754.x" @default.
• W2025446117 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19702629" @default.
• W2025446117 hasPublicationYear "2010" @default.
• W2025446117 type Work @default.
• W2025446117 sameAs 2025446117 @default.
• W2025446117 citedByCount "31" @default.
• W2025446117 countsByYear W20254461172012 @default.
• W2025446117 countsByYear W20254461172013 @default.
• W2025446117 countsByYear W20254461172014 @default.
• W2025446117 countsByYear W20254461172016 @default.
• W2025446117 countsByYear W20254461172017 @default.
• W2025446117 countsByYear W20254461172018 @default.
• W2025446117 countsByYear W20254461172019 @default.
• W2025446117 countsByYear W20254461172020 @default.
• W2025446117 crossrefType "journal-article" @default.
• W2025446117 hasAuthorship W2025446117A5009435222 @default.
• W2025446117 hasAuthorship W2025446117A5022282042 @default.
• W2025446117 hasAuthorship W2025446117A5035633161 @default.
• W2025446117 hasAuthorship W2025446117A5044686047 @default.
• W2025446117 hasAuthorship W2025446117A5051693361 @default.
• W2025446117 hasBestOaLocation W20254461171 @default.
• W2025446117 hasConcept C126322002 @default.
• W2025446117 hasConcept C141071460 @default.
• W2025446117 hasConcept C142462285 @default.
• W2025446117 hasConcept C156957248 @default.
• W2025446117 hasConcept C203014093 @default.
• W2025446117 hasConcept C2777447569 @default.
• W2025446117 hasConcept C2779889181 @default.
• W2025446117 hasConcept C2780580376 @default.
• W2025446117 hasConcept C2780852908 @default.
• W2025446117 hasConcept C2993143319 @default.
• W2025446117 hasConcept C3013748606 @default.
• W2025446117 hasConcept C44249647 @default.
• W2025446117 hasConcept C71924100 @default.
• W2025446117 hasConceptScore W2025446117C126322002 @default.
• W2025446117 hasConceptScore W2025446117C141071460 @default.
• W2025446117 hasConceptScore W2025446117C142462285 @default.
• W2025446117 hasConceptScore W2025446117C156957248 @default.
• W2025446117 hasConceptScore W2025446117C203014093 @default.
• W2025446117 hasConceptScore W2025446117C2777447569 @default.
• W2025446117 hasConceptScore W2025446117C2779889181 @default.
• W2025446117 hasConceptScore W2025446117C2780580376 @default.
• W2025446117 hasConceptScore W2025446117C2780852908 @default.
• W2025446117 hasConceptScore W2025446117C2993143319 @default.
• W2025446117 hasConceptScore W2025446117C3013748606 @default.
• W2025446117 hasConceptScore W2025446117C44249647 @default.
• W2025446117 hasConceptScore W2025446117C71924100 @default.
• W2025446117 hasIssue "2" @default.
• W2025446117 hasLocation W20254461171 @default.
• W2025446117 hasLocation W20254461172 @default.
• W2025446117 hasOpenAccess W2025446117 @default.
• W2025446117 hasPrimaryLocation W20254461171 @default.
• W2025446117 hasRelatedWork W1975492163 @default.
• W2025446117 hasRelatedWork W1978037518 @default.
• W2025446117 hasRelatedWork W1987791325 @default.
• W2025446117 hasRelatedWork W2002808787 @default.
• W2025446117 hasRelatedWork W2006369946 @default.
• W2025446117 hasRelatedWork W2166150294 @default.
• W2025446117 hasRelatedWork W2168148399 @default.
• W2025446117 hasRelatedWork W2414209905 @default.
• W2025446117 hasRelatedWork W4249254932 @default.

• next