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• W2025456810 endingPage "12883" @default.
• W2025456810 startingPage "12883" @default.
• W2025456810 abstract "Gastric cancer surgical management differs between Eastern Asia and Western countries. Extended lymphadenectomy (D2) is the standard of care in Japan and South Korea since decades, while the majority of United States patients receive at most a limited lymphadenectomy (D1). United States and Northern Europe are considered the scientific leaders in medicine and evidence-based procedures are the cornerstone of their clinical practice. However, surgeons in Eastern Asia are more experienced, as there are more new cases of gastric cancer in Japan (107898 in 2012) than in the entire European Union (81592), or in South Korea (31269) than in the entire United States (21155). For quite a long time evidence-based medicine (EBM) did not solve the question whether D2 improves long-term prognosis with respect to D1. Indeed, eastern surgeons were reluctant to perform D1 even in the frame of a clinical trial, as their patients had a very good prognosis after D2. Evidence-based surgical indications provided by Western trials were questioned, as surgical procedures could not be properly standardized. In the present study we analyzed indications about the optimal extension of lymphadenectomy in gastric cancer according to current scientific literature (2008-2012) and surgical guidelines. We searched PubMed for papers using the key words lymphadenectomy or D1 or D2 AND gastric cancer from 2008 to 2012. Moreover, we reviewed national guidelines for gastric cancer management. The support to D2 lymphadenectomy increased progressively from 2008 to 2012: since 2010 papers supporting D2 have achieved a higher overall impact factor than the other papers. Till 2011, D2 was the procedure of choice according to experts' opinion, while three meta-analyses found no survival advantage after D2 with respect to D1. In 2012-2013, however, two meta-analyses reported that D2 improves prognosis with respect to D1. D2 lymphadenectomy was proposed as the standard of care for advanced gastric cancer by Japanese National Guidelines since 1981 and was adopted as the standard procedure by the Italian Research Group for Gastric Cancer since the Nineties. D2 is now indicated as the standard of surgical treatment with curative intent by the German, British and ESMO-ESSO-ESTRO guidelines. At variance American NCCN guidelines recommend a D1(+) or a modified D2 lymph node dissection. In conclusion, D2 lymphadenectomy, originally developed by Eastern surgeons, is now becoming the procedure of choice also in the West. In gastric cancer surgery EBM is lagging behind national guidelines, rather than preceding and orienting them. To eliminate this lag, EBM should value to a larger extent Eastern Asian literature and should evaluate not only the quality of the study design but also the quality of surgical procedures." @default.
• W2025456810 created "2016-06-24" @default.
• W2025456810 creator A5079858070 @default.
• W2025456810 date "2014-01-01" @default.
• W2025456810 modified "2023-10-17" @default.
• W2025456810 title "Problems faced by evidence-based medicine in evaluating lymphadenectomy for gastric cancer" @default.
• W2025456810 cites W108248672 @default.
• W2025456810 cites W1590524909 @default.
• W2025456810 cites W1602642143 @default.
• W2025456810 cites W1732947965 @default.
• W2025456810 cites W1931661444 @default.
• W2025456810 cites W1970107675 @default.
• W2025456810 cites W1974816902 @default.
• W2025456810 cites W1979058887 @default.
• W2025456810 cites W1983641960 @default.
• W2025456810 cites W1985375052 @default.
• W2025456810 cites W1993582108 @default.
• W2025456810 cites W1998542124 @default.
• W2025456810 cites W2004358190 @default.
• W2025456810 cites W2004703674 @default.
• W2025456810 cites W2005787212 @default.
• W2025456810 cites W2007965665 @default.
• W2025456810 cites W2013026031 @default.
• W2025456810 cites W2014449718 @default.
• W2025456810 cites W2015666782 @default.
• W2025456810 cites W2017929862 @default.
• W2025456810 cites W2026343007 @default.
• W2025456810 cites W2031962242 @default.
• W2025456810 cites W2040479946 @default.
• W2025456810 cites W2048658740 @default.
• W2025456810 cites W2050769171 @default.
• W2025456810 cites W2052832177 @default.
• W2025456810 cites W2055481033 @default.
• W2025456810 cites W2056266563 @default.
• W2025456810 cites W2057440670 @default.
• W2025456810 cites W2059576569 @default.
• W2025456810 cites W2060731557 @default.
• W2025456810 cites W2060900419 @default.
• W2025456810 cites W2063320854 @default.
• W2025456810 cites W2067981880 @default.
• W2025456810 cites W2072341469 @default.
• W2025456810 cites W2073253202 @default.
• W2025456810 cites W2075733685 @default.
• W2025456810 cites W2085118973 @default.
• W2025456810 cites W2086652308 @default.
• W2025456810 cites W2087248330 @default.
• W2025456810 cites W2087309925 @default.
• W2025456810 cites W2095462877 @default.
• W2025456810 cites W2096922187 @default.
• W2025456810 cites W2099433579 @default.
• W2025456810 cites W2099522910 @default.
• W2025456810 cites W2099581302 @default.
• W2025456810 cites W2104965946 @default.
• W2025456810 cites W2106033134 @default.
• W2025456810 cites W2106566320 @default.
• W2025456810 cites W2106638985 @default.
• W2025456810 cites W2106640612 @default.
• W2025456810 cites W2108757481 @default.
• W2025456810 cites W2114043825 @default.
• W2025456810 cites W2114489245 @default.
• W2025456810 cites W2117829414 @default.
• W2025456810 cites W2118614385 @default.
• W2025456810 cites W2119311749 @default.
• W2025456810 cites W2119359708 @default.
• W2025456810 cites W2121455177 @default.
• W2025456810 cites W2124614008 @default.
• W2025456810 cites W2125502129 @default.
• W2025456810 cites W2128998354 @default.
• W2025456810 cites W2133593152 @default.
• W2025456810 cites W2134060081 @default.
• W2025456810 cites W2148569409 @default.
• W2025456810 cites W2152225451 @default.
• W2025456810 cites W2157576578 @default.
• W2025456810 cites W2164405594 @default.
• W2025456810 cites W2165277538 @default.
• W2025456810 cites W2169240869 @default.
• W2025456810 cites W2170114310 @default.
• W2025456810 cites W2232101690 @default.
• W2025456810 cites W2316299570 @default.
• W2025456810 cites W2332519812 @default.
• W2025456810 cites W2345499359 @default.
• W2025456810 cites W2414362168 @default.
• W2025456810 cites W2944924994 @default.
• W2025456810 cites W3021688034 @default.
• W2025456810 cites W4211019965 @default.
• W2025456810 cites W4231424126 @default.
• W2025456810 cites W4241305465 @default.
• W2025456810 cites W4246328459 @default.
• W2025456810 cites W4297970198 @default.
• W2025456810 cites W58161282 @default.
• W2025456810 doi "https://doi.org/10.3748/wjg.v20.i36.12883" @default.
• W2025456810 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4177470" @default.
• W2025456810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25278685" @default.
• W2025456810 hasPublicationYear "2014" @default.
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