FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025456860> ?p ?o ?g. }

• W2025456860 endingPage "830" @default.
• W2025456860 startingPage "816" @default.
• W2025456860 abstract "The peripheral taste system presents an excellent model for studying the consequences of neural injury, for the damaged nerve and sensory cells and the neighboring, intact neural cells. Sectioning a primary afferent nerve, the chorda tympani (CT), rapidly recruits neutrophils to both sides of the tongue. The bilateral neutrophil response induces transient functional deficits in the intact CT. Normal function is subsequently restored as macrophages respond to injury. We hypothesized that macrophages produce the proinflammatory cytokine interleukin (IL)-1, which contributes to the maintenance of normal taste function after nearby injury. We demonstrate that IL-1β protein levels are significantly increased on the injured side of the tongue at day 2 after injury. Dietary sodium deficiency, a manipulation that prevents macrophage recruitment, inhibits the elevation in IL-1β. IL-1β was expressed in several cell populations, including taste receptor cells and infiltrating neutrophils and macrophages. To test whether IL-1 modulates taste function after injury, we blocked signaling with an IL-1 receptor antagonist (IL-1 RA) and recorded taste responses from the intact CT. This treatment inhibited the bilateral macrophage response to injury and impaired taste responses in the intact CT. Cytokine actions in the taste system are largely unstudied. These results demonstrate that IL-1 has a beneficial effect on taste function after nearby injury, in contrast to its detrimental role in the injured central nervous system. © 2012 Wiley Periodicals, Inc." @default.
• W2025456860 created "2016-06-24" @default.
• W2025456860 creator A5019307485 @default.
• W2025456860 creator A5060023874 @default.
• W2025456860 creator A5081064913 @default.
• W2025456860 creator A5085361809 @default.
• W2025456860 date "2012-01-02" @default.
• W2025456860 modified "2023-09-26" @default.
• W2025456860 title "Functional role for interleukin-1 in the injured peripheral taste system" @default.
• W2025456860 cites W1591663995 @default.
• W2025456860 cites W1968618759 @default.
• W2025456860 cites W1970808806 @default.
• W2025456860 cites W1970891635 @default.
• W2025456860 cites W1971207325 @default.
• W2025456860 cites W1977494370 @default.
• W2025456860 cites W1978525572 @default.
• W2025456860 cites W1981497047 @default.
• W2025456860 cites W1982215719 @default.
• W2025456860 cites W1988868629 @default.
• W2025456860 cites W1990143831 @default.
• W2025456860 cites W1991634993 @default.
• W2025456860 cites W1997507612 @default.
• W2025456860 cites W2004460437 @default.
• W2025456860 cites W2004524998 @default.
• W2025456860 cites W2006521019 @default.
• W2025456860 cites W2007511428 @default.
• W2025456860 cites W2010691830 @default.
• W2025456860 cites W2011411078 @default.
• W2025456860 cites W2012800318 @default.
• W2025456860 cites W2025072060 @default.
• W2025456860 cites W2030171828 @default.
• W2025456860 cites W2034795729 @default.
• W2025456860 cites W2035478834 @default.
• W2025456860 cites W2035592793 @default.
• W2025456860 cites W2043083000 @default.
• W2025456860 cites W2043217368 @default.
• W2025456860 cites W2043797153 @default.
• W2025456860 cites W2045236203 @default.
• W2025456860 cites W2045751466 @default.
• W2025456860 cites W2047319988 @default.
• W2025456860 cites W2054015893 @default.
• W2025456860 cites W2057658774 @default.
• W2025456860 cites W2059149560 @default.
• W2025456860 cites W2063516674 @default.
• W2025456860 cites W2063697510 @default.
• W2025456860 cites W2069375519 @default.
• W2025456860 cites W2075430896 @default.
• W2025456860 cites W2082028948 @default.
• W2025456860 cites W2091348854 @default.
• W2025456860 cites W2093176989 @default.
• W2025456860 cites W2094676206 @default.
• W2025456860 cites W2097722989 @default.
• W2025456860 cites W2097933114 @default.
• W2025456860 cites W2100150149 @default.
• W2025456860 cites W2105625333 @default.
• W2025456860 cites W2107826905 @default.
• W2025456860 cites W2108080843 @default.
• W2025456860 cites W2112437115 @default.
• W2025456860 cites W2115156649 @default.
• W2025456860 cites W2133557129 @default.
• W2025456860 cites W2138847812 @default.
• W2025456860 cites W2140205768 @default.
• W2025456860 cites W2141220908 @default.
• W2025456860 cites W2145283772 @default.
• W2025456860 cites W2157282220 @default.
• W2025456860 cites W2157871441 @default.
• W2025456860 cites W2158425236 @default.
• W2025456860 cites W2164456902 @default.
• W2025456860 cites W2165275387 @default.
• W2025456860 cites W2166379576 @default.
• W2025456860 cites W4295333450 @default.
• W2025456860 doi "https://doi.org/10.1002/jnr.22798" @default.
• W2025456860 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3274645" @default.
• W2025456860 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22213141" @default.
• W2025456860 hasPublicationYear "2012" @default.
• W2025456860 type Work @default.
• W2025456860 sameAs 2025456860 @default.
• W2025456860 citedByCount "21" @default.
• W2025456860 countsByYear W20254568602012 @default.
• W2025456860 countsByYear W20254568602013 @default.
• W2025456860 countsByYear W20254568602014 @default.
• W2025456860 countsByYear W20254568602016 @default.
• W2025456860 countsByYear W20254568602017 @default.
• W2025456860 countsByYear W20254568602018 @default.
• W2025456860 countsByYear W20254568602019 @default.
• W2025456860 countsByYear W20254568602020 @default.
• W2025456860 countsByYear W20254568602021 @default.
• W2025456860 countsByYear W20254568602022 @default.
• W2025456860 countsByYear W20254568602023 @default.
• W2025456860 crossrefType "journal-article" @default.
• W2025456860 hasAuthorship W2025456860A5019307485 @default.
• W2025456860 hasAuthorship W2025456860A5060023874 @default.
• W2025456860 hasAuthorship W2025456860A5081064913 @default.
• W2025456860 hasAuthorship W2025456860A5085361809 @default.
• W2025456860 hasBestOaLocation W20254568602 @default.
• W2025456860 hasConcept C126322002 @default.
• W2025456860 hasConcept C134018914 @default.
• W2025456860 hasConcept C142724271 @default.

• next