FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025468353> ?p ?o ?g. }

• W2025468353 endingPage "927" @default.
• W2025468353 startingPage "917" @default.
• W2025468353 abstract "Purpose Chronic periodontitis (CP) is a complex immuno-inflammatory disease that results from preestablished gingivitis. We investigated potential differences in salivary peptidome in health and CP. Experimental design Saliva was collected from nine CP patients and ten healthy subjects, from which five CP and five healthy were enriched following endoProteoFASP approach, separated and identified by nanoHPLC-MALDI-TOF/TOF. Protease prediction was carried out in silico with Proteasix. Parallel gelatin and collagen (I) zymographies were performed to study proteolytic activity in CP. Results An association of CP with increased gelatinolytic and collagenolytic activity was observed, which is mainly attributed to metalloproteases, remarkably MMP9. Protease prediction revealed distinct protease profiles in CP and in health. Peptidomic data corroborated the inflammatory status, and demonstrated that intact histatin 1 may play an important role in the defense response against oral pathogens. The application of the endoProteoFASP approach to study the salivary peptidome of CP subjects resulted in the identification of eight surrogate peptide markers, which may be used in multiplex to identify CP. These peptides belong to acidic PRP and to P-B peptide. Particularly, P-B peptide fragments exhibited domains with potential predicted antimicrobial activity, corroborating an antimicrobial function. Conclusions and clinical relevance The comparison between the salivary peptidome obtained by control and CP samples showed a specific association of eight peptides to CP, with remarkable predicted antimicrobial activity, which should be further validated in studies with large number of subjects." @default.
• W2025468353 created "2016-06-24" @default.
• W2025468353 creator A5001343827 @default.
• W2025468353 creator A5029372509 @default.
• W2025468353 creator A5042300177 @default.
• W2025468353 creator A5045393131 @default.
• W2025468353 creator A5066319573 @default.
• W2025468353 creator A5069991000 @default.
• W2025468353 creator A5072542055 @default.
• W2025468353 creator A5075468536 @default.
• W2025468353 creator A5088906026 @default.
• W2025468353 date "2015-05-08" @default.
• W2025468353 modified "2023-10-14" @default.
• W2025468353 title "Toward the definition of a peptidome signature and protease profile in chronic periodontitis" @default.
• W2025468353 cites W1492374164 @default.
• W2025468353 cites W1880624715 @default.
• W2025468353 cites W1915678697 @default.
• W2025468353 cites W1928512488 @default.
• W2025468353 cites W1934857244 @default.
• W2025468353 cites W1939113199 @default.
• W2025468353 cites W1965664664 @default.
• W2025468353 cites W1969930465 @default.
• W2025468353 cites W1970808795 @default.
• W2025468353 cites W1974639494 @default.
• W2025468353 cites W1979916279 @default.
• W2025468353 cites W1980710411 @default.
• W2025468353 cites W1981004429 @default.
• W2025468353 cites W1992683021 @default.
• W2025468353 cites W1998666583 @default.
• W2025468353 cites W2002815984 @default.
• W2025468353 cites W2017660638 @default.
• W2025468353 cites W2019675891 @default.
• W2025468353 cites W2036273044 @default.
• W2025468353 cites W2051654094 @default.
• W2025468353 cites W2067174401 @default.
• W2025468353 cites W2079692416 @default.
• W2025468353 cites W2082832774 @default.
• W2025468353 cites W2086311277 @default.
• W2025468353 cites W2090072019 @default.
• W2025468353 cites W2091505703 @default.
• W2025468353 cites W2092236356 @default.
• W2025468353 cites W2095607085 @default.
• W2025468353 cites W2095917090 @default.
• W2025468353 cites W2099204677 @default.
• W2025468353 cites W2102935340 @default.
• W2025468353 cites W2106671334 @default.
• W2025468353 cites W2118470591 @default.
• W2025468353 cites W2118710484 @default.
• W2025468353 cites W2129115651 @default.
• W2025468353 cites W2142513160 @default.
• W2025468353 cites W2151010282 @default.
• W2025468353 cites W2163868932 @default.
• W2025468353 cites W2169589032 @default.
• W2025468353 cites W2169836613 @default.
• W2025468353 cites W2174784305 @default.
• W2025468353 cites W2079513165 @default.
• W2025468353 doi "https://doi.org/10.1002/prca.201400191" @default.
• W2025468353 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25669956" @default.
• W2025468353 hasPublicationYear "2015" @default.
• W2025468353 type Work @default.
• W2025468353 sameAs 2025468353 @default.
• W2025468353 citedByCount "21" @default.
• W2025468353 countsByYear W20254683532016 @default.
• W2025468353 countsByYear W20254683532017 @default.
• W2025468353 countsByYear W20254683532018 @default.
• W2025468353 countsByYear W20254683532019 @default.
• W2025468353 countsByYear W20254683532020 @default.
• W2025468353 countsByYear W20254683532021 @default.
• W2025468353 countsByYear W20254683532023 @default.
• W2025468353 crossrefType "journal-article" @default.
• W2025468353 hasAuthorship W2025468353A5001343827 @default.
• W2025468353 hasAuthorship W2025468353A5029372509 @default.
• W2025468353 hasAuthorship W2025468353A5042300177 @default.
• W2025468353 hasAuthorship W2025468353A5045393131 @default.
• W2025468353 hasAuthorship W2025468353A5066319573 @default.
• W2025468353 hasAuthorship W2025468353A5069991000 @default.
• W2025468353 hasAuthorship W2025468353A5072542055 @default.
• W2025468353 hasAuthorship W2025468353A5075468536 @default.
• W2025468353 hasAuthorship W2025468353A5088906026 @default.
• W2025468353 hasConcept C104317684 @default.
• W2025468353 hasConcept C109523444 @default.
• W2025468353 hasConcept C126322002 @default.
• W2025468353 hasConcept C181199279 @default.
• W2025468353 hasConcept C185592680 @default.
• W2025468353 hasConcept C2775905019 @default.
• W2025468353 hasConcept C2776714187 @default.
• W2025468353 hasConcept C2779281246 @default.
• W2025468353 hasConcept C2779337755 @default.
• W2025468353 hasConcept C2780385504 @default.
• W2025468353 hasConcept C4937899 @default.
• W2025468353 hasConcept C504460877 @default.
• W2025468353 hasConcept C540938839 @default.
• W2025468353 hasConcept C55493867 @default.
• W2025468353 hasConcept C55728118 @default.
• W2025468353 hasConcept C71924100 @default.
• W2025468353 hasConcept C86803240 @default.
• W2025468353 hasConcept C89423630 @default.
• W2025468353 hasConceptScore W2025468353C104317684 @default.

• next