FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025482915> ?p ?o ?g. }

• W2025482915 endingPage "135" @default.
• W2025482915 startingPage "129" @default.
• W2025482915 abstract "A new search for mitochondrial respiratory deficient mutants (Mit-) has been undertaken in order to accumulate a large number of point mutations in the coding portions of cytochrome-c-oxidase catalytic subunits and cytochrome b. Therefore, a mitochondrial DNA which retains the exons and lacks all the introns of the cytochrome oxidase subunit I and of the cytochrome-b split genes has been introduced into a strain carrying a nuclear recessive mutation affecting the adenine-nucleotide translocator, the op1 mutation, which is known to prevent the accumulation of large deletion petite mutants and this was used as the parental strain. After a moderate MnCl2 mutagenesis in order to limit multiple mutations, 105 Mit- mutants were isolated from 15,000 mutagenised clones in Saccharomyces cerevisiae. Mutations were mapped to the three catalytic subunits encoding genes (COX1, COX2 and COX3) of the cytochrome-c oxidase (70 mutations) and to the cytochrome-b gene (15 mutations). More than 50% of the mutants tested still exhibited mitochondrial translation products (subunits I, II and III), suggesting that they carry a missense mutation, rather than a nonsense mutation which would normally have led to a truncated protein. Mutations in the COX1 gene were allocated to four different subregions corresponding to exons 4 and 8 or to groups of exons, exons 1, 2, 3 or exons 5, 6, 7. Seven missense monosubstitution mutations and two frameshift mutations were also identified. The amino acid changes of the missense mutations were located in the vicinity of the CuB-heme alpha 3 binuclear centre ligands." @default.
• W2025482915 created "2016-06-24" @default.
• W2025482915 creator A5040421668 @default.
• W2025482915 creator A5079591293 @default.
• W2025482915 creator A5088420809 @default.
• W2025482915 date "1993-04-01" @default.
• W2025482915 modified "2023-09-24" @default.
• W2025482915 title "Genetic screening in Saccharomyces cerevisiae for large numbers of mitochondrial point mutations which affect structure and function of catalytic subunits of cytochrome-c oxidase" @default.
• W2025482915 cites W1246794412 @default.
• W2025482915 cites W1538319771 @default.
• W2025482915 cites W1544916933 @default.
• W2025482915 cites W1558760409 @default.
• W2025482915 cites W1566265554 @default.
• W2025482915 cites W1579749395 @default.
• W2025482915 cites W1590226237 @default.
• W2025482915 cites W1967086186 @default.
• W2025482915 cites W1968656994 @default.
• W2025482915 cites W1984781682 @default.
• W2025482915 cites W2004483896 @default.
• W2025482915 cites W2013510750 @default.
• W2025482915 cites W2035776094 @default.
• W2025482915 cites W2042810205 @default.
• W2025482915 cites W2044475101 @default.
• W2025482915 cites W2060005245 @default.
• W2025482915 cites W2068825288 @default.
• W2025482915 cites W2084727384 @default.
• W2025482915 cites W2132763099 @default.
• W2025482915 cites W2147148910 @default.
• W2025482915 cites W2946165117 @default.
• W2025482915 cites W44216643 @default.
• W2025482915 doi "https://doi.org/10.1111/j.1432-1033.1993.tb17742.x" @default.
• W2025482915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8386619" @default.
• W2025482915 hasPublicationYear "1993" @default.
• W2025482915 type Work @default.
• W2025482915 sameAs 2025482915 @default.
• W2025482915 citedByCount "25" @default.
• W2025482915 countsByYear W20254829152012 @default.
• W2025482915 countsByYear W20254829152014 @default.
• W2025482915 countsByYear W20254829152017 @default.
• W2025482915 countsByYear W20254829152020 @default.
• W2025482915 countsByYear W20254829152021 @default.
• W2025482915 crossrefType "journal-article" @default.
• W2025482915 hasAuthorship W2025482915A5040421668 @default.
• W2025482915 hasAuthorship W2025482915A5079591293 @default.
• W2025482915 hasAuthorship W2025482915A5088420809 @default.
• W2025482915 hasConcept C104317684 @default.
• W2025482915 hasConcept C123249941 @default.
• W2025482915 hasConcept C143065580 @default.
• W2025482915 hasConcept C148292235 @default.
• W2025482915 hasConcept C153911025 @default.
• W2025482915 hasConcept C176944494 @default.
• W2025482915 hasConcept C24586158 @default.
• W2025482915 hasConcept C2777576037 @default.
• W2025482915 hasConcept C28859421 @default.
• W2025482915 hasConcept C29906990 @default.
• W2025482915 hasConcept C36823959 @default.
• W2025482915 hasConcept C501734568 @default.
• W2025482915 hasConcept C54355233 @default.
• W2025482915 hasConcept C75563809 @default.
• W2025482915 hasConcept C82880906 @default.
• W2025482915 hasConcept C86803240 @default.
• W2025482915 hasConcept C96777560 @default.
• W2025482915 hasConceptScore W2025482915C104317684 @default.
• W2025482915 hasConceptScore W2025482915C123249941 @default.
• W2025482915 hasConceptScore W2025482915C143065580 @default.
• W2025482915 hasConceptScore W2025482915C148292235 @default.
• W2025482915 hasConceptScore W2025482915C153911025 @default.
• W2025482915 hasConceptScore W2025482915C176944494 @default.
• W2025482915 hasConceptScore W2025482915C24586158 @default.
• W2025482915 hasConceptScore W2025482915C2777576037 @default.
• W2025482915 hasConceptScore W2025482915C28859421 @default.
• W2025482915 hasConceptScore W2025482915C29906990 @default.
• W2025482915 hasConceptScore W2025482915C36823959 @default.
• W2025482915 hasConceptScore W2025482915C501734568 @default.
• W2025482915 hasConceptScore W2025482915C54355233 @default.
• W2025482915 hasConceptScore W2025482915C75563809 @default.
• W2025482915 hasConceptScore W2025482915C82880906 @default.
• W2025482915 hasConceptScore W2025482915C86803240 @default.
• W2025482915 hasConceptScore W2025482915C96777560 @default.
• W2025482915 hasIssue "1" @default.
• W2025482915 hasLocation W20254829151 @default.
• W2025482915 hasLocation W20254829152 @default.
• W2025482915 hasOpenAccess W2025482915 @default.
• W2025482915 hasPrimaryLocation W20254829151 @default.
• W2025482915 hasRelatedWork W1540914548 @default.
• W2025482915 hasRelatedWork W179064230 @default.
• W2025482915 hasRelatedWork W1979176079 @default.
• W2025482915 hasRelatedWork W1982070672 @default.
• W2025482915 hasRelatedWork W2006550622 @default.
• W2025482915 hasRelatedWork W2062795483 @default.
• W2025482915 hasRelatedWork W2081165832 @default.
• W2025482915 hasRelatedWork W2563502922 @default.
• W2025482915 hasRelatedWork W2594801 @default.
• W2025482915 hasRelatedWork W306848151 @default.
• W2025482915 hasVolume "213" @default.
• W2025482915 isParatext "false" @default.
• W2025482915 isRetracted "false" @default.
• W2025482915 magId "2025482915" @default.

• next