Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025485685> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2025485685 endingPage "607" @default.
- W2025485685 startingPage "604" @default.
- W2025485685 abstract "Myocardial xanthine oxidase has been associated with reoxygenation injury induced by oxygen radicals. The damage due to myocardial ischemia and reperfusion increases with age; therefore, one would expect to find more xanthine oxidase in adult than in young hearts. Consequently, we studied the age-dependence of xanthine oxidoreductase activity in hearts, in addition to the localization of the enzyme in cultured rat-heart cells. We measured xanthine oxidase plus dehydrogenase activity in homogenates of hearts and in homogenates of cultured neonatal myocytes and nonmuscular cells. In rat heart homogenates, xanthine oxidoreductase increased from 0.5 +/- 0.1 mU/g wet wt (newborn, mean +/- SD) to 25 +/- 4 mU/g (age 15 weeks, p less than 0.001). The value for adult rabbit heart was more than 1,000 times lower and hardly detectable. Therefore, we did not study young rabbit hearts. In rat myocyte cultures, xanthine oxidoreductase activity increased from 4.2 +/- 1.6 mU/g protein (2nd day of culture) to 17 +/- 4 mU/g (4th day, p less than 0.005). The activity in nonmuscular cells increased much more, from 10.1 +/- 1.1 to 117 +/- 25 mU/g (p less than 0.002). The age-related increase of xanthine oxidoreductase activity in rat heart is in agreement with the implied role in reperfusion damage by the enzyme. Whether myocytes, in which the enzyme has a low activity, could be damaged in this way, remains to be studied." @default.
- W2025485685 created "2016-06-24" @default.
- W2025485685 creator A5045666878 @default.
- W2025485685 creator A5075411501 @default.
- W2025485685 date "1987-10-01" @default.
- W2025485685 modified "2023-09-26" @default.
- W2025485685 title "Age-dependent increase in xanthine oxidoreductase differs in various heart cell types." @default.
- W2025485685 cites W1497458285 @default.
- W2025485685 cites W1785504137 @default.
- W2025485685 cites W1943979119 @default.
- W2025485685 cites W1982614687 @default.
- W2025485685 cites W1993385736 @default.
- W2025485685 cites W2007580475 @default.
- W2025485685 cites W2034683799 @default.
- W2025485685 cites W2034878415 @default.
- W2025485685 cites W2052811636 @default.
- W2025485685 cites W2053576402 @default.
- W2025485685 cites W2060933702 @default.
- W2025485685 cites W2069571219 @default.
- W2025485685 cites W2076204859 @default.
- W2025485685 cites W2078871261 @default.
- W2025485685 cites W2094379315 @default.
- W2025485685 cites W4293247451 @default.
- W2025485685 doi "https://doi.org/10.1161/01.res.61.4.604" @default.
- W2025485685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3477338" @default.
- W2025485685 hasPublicationYear "1987" @default.
- W2025485685 type Work @default.
- W2025485685 sameAs 2025485685 @default.
- W2025485685 citedByCount "30" @default.
- W2025485685 countsByYear W20254856852020 @default.
- W2025485685 crossrefType "journal-article" @default.
- W2025485685 hasAuthorship W2025485685A5045666878 @default.
- W2025485685 hasAuthorship W2025485685A5075411501 @default.
- W2025485685 hasBestOaLocation W20254856851 @default.
- W2025485685 hasConcept C126322002 @default.
- W2025485685 hasConcept C134018914 @default.
- W2025485685 hasConcept C151400659 @default.
- W2025485685 hasConcept C16685009 @default.
- W2025485685 hasConcept C181199279 @default.
- W2025485685 hasConcept C185592680 @default.
- W2025485685 hasConcept C207200792 @default.
- W2025485685 hasConcept C2778102346 @default.
- W2025485685 hasConcept C2779268744 @default.
- W2025485685 hasConcept C2779470414 @default.
- W2025485685 hasConcept C28212737 @default.
- W2025485685 hasConcept C55493867 @default.
- W2025485685 hasConcept C71924100 @default.
- W2025485685 hasConcept C86803240 @default.
- W2025485685 hasConceptScore W2025485685C126322002 @default.
- W2025485685 hasConceptScore W2025485685C134018914 @default.
- W2025485685 hasConceptScore W2025485685C151400659 @default.
- W2025485685 hasConceptScore W2025485685C16685009 @default.
- W2025485685 hasConceptScore W2025485685C181199279 @default.
- W2025485685 hasConceptScore W2025485685C185592680 @default.
- W2025485685 hasConceptScore W2025485685C207200792 @default.
- W2025485685 hasConceptScore W2025485685C2778102346 @default.
- W2025485685 hasConceptScore W2025485685C2779268744 @default.
- W2025485685 hasConceptScore W2025485685C2779470414 @default.
- W2025485685 hasConceptScore W2025485685C28212737 @default.
- W2025485685 hasConceptScore W2025485685C55493867 @default.
- W2025485685 hasConceptScore W2025485685C71924100 @default.
- W2025485685 hasConceptScore W2025485685C86803240 @default.
- W2025485685 hasIssue "4" @default.
- W2025485685 hasLocation W20254856851 @default.
- W2025485685 hasLocation W20254856852 @default.
- W2025485685 hasOpenAccess W2025485685 @default.
- W2025485685 hasPrimaryLocation W20254856851 @default.
- W2025485685 hasRelatedWork W1521468003 @default.
- W2025485685 hasRelatedWork W1753158170 @default.
- W2025485685 hasRelatedWork W1918251660 @default.
- W2025485685 hasRelatedWork W2022415318 @default.
- W2025485685 hasRelatedWork W2025485685 @default.
- W2025485685 hasRelatedWork W2040806338 @default.
- W2025485685 hasRelatedWork W2065428823 @default.
- W2025485685 hasRelatedWork W2076786241 @default.
- W2025485685 hasRelatedWork W2151352818 @default.
- W2025485685 hasRelatedWork W1997463885 @default.
- W2025485685 hasVolume "61" @default.
- W2025485685 isParatext "false" @default.
- W2025485685 isRetracted "false" @default.
- W2025485685 magId "2025485685" @default.
- W2025485685 workType "article" @default.