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• W2025488549 abstract "<h3>AIMS</h3> Overexpression of<i>c-myc</i> protein has independent prognostic significance in a variety of primary and metastatic cutaneous melanomas which suggests a possible role for this gene in melanomagenesis. We have therefore examined the importance of this oncogene in uveal melanoma and studied the coexpression of two other gene products,<i>Bcl-2</i> and<i> p53</i>, which might contribute to its effect. <h3>METHODS</h3> The percentage of cells positive for nuclear <i>c-myc</i>expression was estimated by flow cytometric analysis of nuclei extracted from paraffin blocks. The expression of<i>Bcl-2</i> and <i>p53</i>protein was assessed by immunohistochemistry. A total of 71 tumours were studied and the results compared with survival with a mean follow up period of 6 years. <h3>RESULTS</h3> <i>c-myc</i>was expressed in >50% of the cells by 70% of the tumours, and was independently associated with improved survival in a Cox multiple regression model. Although <i>Bcl-2</i> was expressed by the majority of the cells in 67% tumours, it was without effect on prognosis. None of the cases studied showed convincing positivity for<i> p53</i>. Analysis of coexpression showed that the best survival was seen in<i>c-myc</i>+/<i>Bcl-2</i>+ tumours and the worst in<i>c-myc</i>−/<i>Bcl-2−</i>tumours. <h3>CONCLUSION</h3> The finding of improved rather than reduced survival in<i>c-myc</i> positive tumours is at variance with skin melanoma. There was no evidence to suggest that<i>c-myc</i> was modulated by upregulation of<i>Bcl-2</i> or<i> p53</i>inactivation/mutation. Although <i>Bcl-2</i> is unlikely to have any effect on tumour growth or metastasis, it could contribute to the general lack of susceptibility to apoptosis in these tumours." @default.
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• W2025488549 date "1999-01-01" @default.
• W2025488549 modified "2023-10-14" @default.
• W2025488549 title "c-myc, p53, and Bcl-2 expression and clinical outcome in uveal melanoma" @default.
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• W2025488549 doi "https://doi.org/10.1136/bjo.83.1.110" @default.
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