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• W2025492041 abstract "We describe a novel procedure to load amphipathic weak acid molecules into preformed liposomes. Differences in calcium acetate concentrations across the liposomal membrane induce an increase of the internal pH. This pH imbalance serves as an efficient driving force to load and accumulate weak acids (5(6)-carboxyfluorescein and nalidixic acid) inside the lipid vesicles. The mechanism of loading and the relevance of the method in drug delivery systems are discussed." @default.
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• W2025492041 date "1995-12-01" @default.
• W2025492041 modified "2023-10-18" @default.
• W2025492041 title "Loading of amphipathic weak acids into liposomes in response to transmembrane calcium acetate gradients" @default.
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• W2025492041 doi "https://doi.org/10.1016/0005-2736(95)00214-6" @default.
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