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• W2025505853 abstract "We calculate the forces required to package (or, equivalently, acting to eject) DNA into (from) a bacteriophage capsid, as a function of the loaded (ejected) length, under conditions for which the DNA is either self-repelling or self-attracting. Through computer simulation and analytical theory, we find the loading force to increase more than 10-fold (to tens of piconewtons) during the final third of the loading process; correspondingly, the internal pressure drops 10-fold to a few atmospheres (matching the osmotic pressure in the cell) upon ejection of just a small fraction of the phage genome. We also determine an evolution of the arrangement of packaged DNA from toroidal to spool-like structures." @default.
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• W2025505853 date "2001-11-13" @default.
• W2025505853 modified "2023-09-27" @default.
• W2025505853 title "DNA packaging and ejection forces in bacteriophage" @default.
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• W2025505853 doi "https://doi.org/10.1073/pnas.241486298" @default.
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