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• W2025518062 abstract "Purpose To evaluate a susceptibility-corrected multiecho magnetic resonance (MR) relaxometry technique for an accurate and robust determination of ΔR2* as a noninvasive surrogate parameter of the perfused tumor blood volume. Materials and Methods All experiments were approved by the institutional animal care committee. In a glass tube phantom with different superparamagnetic iron oxide (SPIO) particle concentrations and at tumor mice xenografts with DU-4475, HT-1080, and MDA-MB-435 tumors (n = 15 total, n = 5 per model) with different degrees of neovascularization after injection of different ultrasmall SPIO (USPIO) doses changes of the transverse relaxation rate (ΔR2*) were determined by using a fixed echo time (TE) of 22 msec and a susceptibility-corrected multigradient-echo technique. The mean ΔR2* value and the vascular volume fraction (VVF) of each tumor was determined and compared with independent in vivo fluorescent tumor perfusion measurements and histologic analysis helped determine microvessel density (MVD). Statistical differences were tested by using analysis of variance and linear correlations. Results For the phantom study, ΔR2* maps calculated with a fixed TE of 22 msec showed a higher standard deviation of the noise index compared with the susceptibility-corrected multiecho technique. For the xenograft model, mean tumor ΔR2* values (± standard error of the mean) showed significant differences between the various tumors (eg, DU-4475: 12.3 sec–1 ± 2.67, HT-1080: 36.47 sec–1 ± 5.84, and MDA-MB-435: 64.01 sec–1 ± 8.87 at 80 μmol of iron per kilogram; P < .05). ΔR2* values increased dose dependently and in a linear fashion, resulting in reproducibly stable VVF measurements. Fluorescent tumor perfusion measurements and MVD counts corroborated the MR results. Conclusion Susceptibility-corrected multiecho MR relaxometry allows a highly accurate and robust determination of ΔR2* and VVF with an excellent dynamic range for tumor characterization at clinically relevant doses of USPIO. © RSNA, 2010" @default.
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• W2025518062 date "2010-06-01" @default.
• W2025518062 modified "2023-10-18" @default.
• W2025518062 title "Tumor Blood Volume Determination by Using Susceptibility-corrected ΔR2* Multiecho MR" @default.
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• W2025518062 doi "https://doi.org/10.1148/radiol.10090832" @default.
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