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- W2025519683 abstract "Previous studies from our laboratory showed that HSYA significantly reduced the myocardial infarct size. The aim of this study is to evaluate effect of HSYA combined with nitroglycerin on acute myocardial infarction. Fifty SD rats were randomly divided into five groups with ten rats in each group: control group (NS 1 ml/100 g), model group (NS 1 ml/100 g), HSYA group (10 mg/kg), nitroglycerin (NTG) group (0.3 mg/kg) and HSYA+NTG group (10 mg/kg+0.3 mg/kg). After the left anterior descending branch of the coronary artery ligation except the sham group the rats were administered immediately the drug by intraperitoneal injection. Six hours later, the myocardial infarct size (MIS), creatine kinase activity (CK-MB), endothelial nitric oxide synthase activity (eNOS), superoxide dismutase activity (SOD), malondialdehyde content (MDA), nitric oxide content (NO) were measured. The results showed that HSYA, NTG had significant cardioprotective effects. Compared with HSYA group or NTG group, the rats treated with HSYA and NTG produced a marked reduction in MIS (P<0.01). HSYA and NTG significantly inhibited the elevation of the activity of CK-MB and the content of MDA (P<0.05 or P<0.01). HSYA and NTG also showed an obviously capacity to increase the activity of SOD, eNOS and NO content (P<0.05 or P<0.01). The findings suggested that the therapeutic action of HSYA combined with NTG on acute myocardial infarction is better than treat with HSYA or NTG alone. (NO) was measured. The results showed that HSYA, NTG had significant cardioprotective effects. Compared with HSYA group or NTG group, the rats treated with HSYA and NTG produced a marked reduction in MIS (P<0.01). HSYA and NTG significantly inhibited the elevation of the activity of CK-MB and the content of MDA (P<0.05 or P<0.01). HSYA and NTG also showed an obviously capacity to increase the activity of SOD, eNOS and NO content (P<0.05 or P<0.01). The findings suggested that the therapeutic action of HSYA combined with NTG on acute myocardial infarction is better than treated with HSYA or NTG alone." @default.
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- W2025519683 date "2007-06-01" @default.
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- W2025519683 title "Effect of hydroxysafflor yellow a combined with nitroglycerin on acute myocardial infarction" @default.
- W2025519683 doi "https://doi.org/10.1016/j.yjmcc.2007.03.653" @default.
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