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- W2025522110 abstract "Nonsteroidal anti-oestrogenic drugs, tamoxifen and clomiphene citrate, at concentrations higher than 0.001 mug/ml reduced the colony forming ability of cells derived from a rat uterine adenocarcinoma in vitro. The 50 per cent inhibitory dose of these drugs was about one-hundredth of that of sex steroids. When the cells were treated with combinations of these nonsteroidal anti-oestrogenic drugs and the 50 per cent inhibitory dose (8 mug/ml) of progesterone, a synergistic effect on the inhibition of colony formation was observed. In contrast to progesterone, oestradiol-17beta (the 50 per cent inhibitory dose of which was about 16 mug/ml) suppressed additively the colony formation only in combination with low doses of anti-oestrogenic drugs." @default.
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- W2025522110 date "1976-03-01" @default.
- W2025522110 modified "2023-10-14" @default.
- W2025522110 title "THE COMBINED EFFECT OF NONSTEROIDAL ANTI-OESTROGENS AND SEX STEROIDS ON THE GROWTH OF RAT UTERINE ADENOCARCINOMA CELLS IN TISSUE CULTURE" @default.
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- W2025522110 doi "https://doi.org/10.1111/j.1471-0528.1976.tb00806.x" @default.
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