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- W2025530770 endingPage "S122" @default.
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- W2025530770 abstract "Antiviral therapy of chronic hepatitis B remains a clinical challenge. The primary goal of therapy is to prevent liver disease progression. Because of the mechanism of viral persistence in infected hepatocytes, long-term antiviral therapy is needed in the majority of patients. Incomplete viral suppression and emergence of drug resistance is a major concern. The correct choice of a first-line potent therapy to achieve sustained long-term suppression of viral replication provides the best chance of preventing treatment failure and drug resistance. Clinical studies have demonstrated that drugs with a high barrier to resistance, such as entecavir and tenofovir, have significantly lower rates of resistance when compared with those with a low barrier to resistance such as lamivudine, adefovir, or telbivudine. Management of treatment failure requires a precise clinical and accurate virologic monitoring as well as an early treatment intervention with appropriate complementary drugs with respect to their cross-resistance profile. Long-term surveillance for treatment efficacy and possible emergence of drug resistance is necessary for those patients who have been sequentially treated with multiple antivirals. Finally, the identification of novel treatment targets remains a major research challenge to improve the efficacy of current antiviral therapy." @default.
- W2025530770 created "2016-06-24" @default.
- W2025530770 creator A5063172143 @default.
- W2025530770 creator A5085621586 @default.
- W2025530770 date "2012-01-01" @default.
- W2025530770 modified "2023-10-07" @default.
- W2025530770 title "Management of treatment failure in chronic hepatitis B" @default.
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- W2025530770 doi "https://doi.org/10.1016/s0168-8278(12)60012-9" @default.
- W2025530770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22300461" @default.
- W2025530770 hasPublicationYear "2012" @default.
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