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- W2025548082 abstract "Met-enkephalin and its Pro5 analogs containing Gly or D amino acids at position 2 were subjected to digestion with aminopeptidase M, rat brain extracts and human sera. The enzyme resistance of these peptides was compared with their analgesic activity determined in tail flick test after central and intravenous administrations. Our data did not reveal an unambigous correlation between the analgesic potency and metabolic stability of the analogs. This suggest that analgesic activity of synthetic peptides should be due to factors other than enzyme resistance /e.g. receptor binding and transport properties/." @default.
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- W2025548082 date "1978-10-01" @default.
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- W2025548082 title "Is there correlation between analgesic potency and biodegradation of enkephalin analogs?" @default.
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- W2025548082 doi "https://doi.org/10.1016/0006-291x(78)91689-3" @default.
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