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- W202554944 abstract "textabstractIn this thesis we first describe what is known from the literature on the effect ofasthma drugs on airway responsiveness to histamine and methacholine (ChapterII).Chapter Ill describes the results of an acute effect study of an inhaled corticosteroidon AHR (sensitivity) to methacholine.In Chapter IV a study in children in which the effect of an inhaled corticosteroid wascompared with the effect of a beta,-agonist on airway caliber, airwayresponsiveness to methacholine and symptoms during a period of 6 months isdescribed.Chapter V describes the results of the first part of the multicenter study, in whichthe effect of long-term treatment with an inhaled beta,-agonist plus an inhaledcorticosteroid was compared with the effect of an inhaled beta,-agonist-only onclinical endpoints, airway caliber, bronchodilator response and airwayresponsiveness to histamine. This part had to be discontinued after a mediantreatment period of 22 months because of the high withdrawal rate in the beta,agonist-only group.The second part of the study was concerned with the continuation of the patientson beta,-agonist plus inhaled corticosteroid up to 28 to 36 months afterrandomization, in which the further course of endpoints was studied and theremission rate was evaluated. The results are described in Chapter VI.The third part deals with the effect of cessation of inhaled corticosteroid in thosechildren on inhaled corticosteroid who had a follow-up of at least 28 months onJuly 1, 1991 (Chapter VII)." @default.
- W202554944 created "2016-06-24" @default.
- W202554944 creator A5079231126 @default.
- W202554944 date "1993-03-31" @default.
- W202554944 modified "2023-09-26" @default.
- W202554944 title "Long-term intervention in childhood asthma" @default.
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- W202554944 hasPublicationYear "1993" @default.