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- W2025558602 abstract "The human genome contains at least six homologues of the apolipoprotein(a) and plasminogen genes, which contain over 90% identity in the region corresponding to 5' flanking sequences and exon one. This region of the apolipoprotein(a) gene contains transcription control elements, and sequence differences in this region account for some of the variation in plasma Lp(a) concentration. Transgenic mice expressing human apolipoprotein(a) develop aortic lesions resembling the early stages of human atherosclerosis after 3.5 months on a high fat diet. The transgenic mouse model should prove a useful system for studying the role of apolipoprotein(a) in disease." @default.
- W2025558602 created "2016-06-24" @default.
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- W2025558602 date "1994-01-01" @default.
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- W2025558602 title "The apolipoprotein(a) gene: characterization of 5′ flanking regions and expression in transgenic mice" @default.
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- W2025558602 doi "https://doi.org/10.1016/0009-3084(94)90120-1" @default.
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