Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025562571> ?p ?o ?g. }
- W2025562571 abstract "By an analysis of PDB crystal structures, the mean conformations of protein strands bound in serine protease active sites are shown to contain extensively aligned atomic orbitals. The active-serine-bearing segment of each enzyme (subtilisin BPN' and beta-trypsin) also contains such alignments. The participating orbitals are almost identical in each system. All of the alignments converge on the targeted linkage. They suggest that a kind of through-strand polarizability is being optimized by evolution, presumably due to corresponding benefits in proteolysis rate. Such polarizability would help to explain the high values of kcat seen for long oligopeptide substrates. The idea predicts long substrates to be relatively reactive even under non-enzymatic conditions, which in fact they are." @default.
- W2025562571 created "2016-06-24" @default.
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- W2025562571 date "2004-06-01" @default.
- W2025562571 modified "2023-09-25" @default.
- W2025562571 title "Intramolecular orbital alignments in serine protease/protein inhibitor complexes" @default.
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- W2025562571 doi "https://doi.org/10.1016/j.bmc.2004.02.044" @default.
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