FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2025565532> ?p ?o ?g. }

• W2025565532 endingPage "972" @default.
• W2025565532 startingPage "962" @default.
• W2025565532 abstract "Abstract Phosphorylation of eIF4E by human mitogen‐activated protein kinase (MAPK)‐interacting kinases (Mnks) is crucial for human tumourigenesis and development. Targeting Mnks may provide a novel anticancer therapeutic strategy. However, the lack of selective Mnk inhibitors has so far hampered pharmacological target validation and clinical drug development. Herein, we report, for the first time, the discovery of a series of 5‐(2‐(phenylamino)pyrimidin‐4‐yl)thiazole‐2(3 H )‐one derivatives as Mnk inhibitors. Several derivatives demonstrate very potent Mnk2 inhibitory activity. The most active and selective compounds were tested against a panel of cancer cell lines, and the results confirm the cell‐type‐specific effect of these Mnk inhibitors. Detailed cellular mechanistic studies reveal that Mnk inhibitors are capable of reducing the expression level of anti‐apoptotic protein Mcl‐1, and of promoting apoptosis in MV4‐11 acute myeloid leukaemia cells." @default.
• W2025565532 created "2016-06-24" @default.
• W2025565532 creator A5002750621 @default.
• W2025565532 creator A5023170050 @default.
• W2025565532 creator A5030623527 @default.
• W2025565532 creator A5042380073 @default.
• W2025565532 creator A5043798697 @default.
• W2025565532 creator A5048094266 @default.
• W2025565532 creator A5058816305 @default.
• W2025565532 creator A5059216740 @default.
• W2025565532 creator A5066141484 @default.
• W2025565532 creator A5071458554 @default.
• W2025565532 creator A5076511286 @default.
• W2025565532 date "2014-02-12" @default.
• W2025565532 modified "2023-10-11" @default.
• W2025565532 title "Discovery of 5-(2-(Phenylamino)pyrimidin-4-yl)thiazol-2(3<i>H</i>)-one Derivatives as Potent Mnk2 Inhibitors: Synthesis, SAR Analysis and Biological Evaluation" @default.
• W2025565532 cites W1968919723 @default.
• W2025565532 cites W1972648122 @default.
• W2025565532 cites W1976198410 @default.
• W2025565532 cites W1985588649 @default.
• W2025565532 cites W1986308117 @default.
• W2025565532 cites W1997263291 @default.
• W2025565532 cites W2009423060 @default.
• W2025565532 cites W2016365699 @default.
• W2025565532 cites W2030801461 @default.
• W2025565532 cites W2031119437 @default.
• W2025565532 cites W2038146634 @default.
• W2025565532 cites W2046822015 @default.
• W2025565532 cites W2084585145 @default.
• W2025565532 cites W2091226837 @default.
• W2025565532 cites W2096911348 @default.
• W2025565532 cites W2100468603 @default.
• W2025565532 cites W2102889876 @default.
• W2025565532 cites W2110364290 @default.
• W2025565532 cites W2111255040 @default.
• W2025565532 cites W2111686163 @default.
• W2025565532 cites W2112811927 @default.
• W2025565532 cites W2121647526 @default.
• W2025565532 cites W2129615992 @default.
• W2025565532 cites W2132519593 @default.
• W2025565532 cites W2158850252 @default.
• W2025565532 doi "https://doi.org/10.1002/cmdc.201300552" @default.
• W2025565532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24677692" @default.
• W2025565532 hasPublicationYear "2014" @default.
• W2025565532 type Work @default.
• W2025565532 sameAs 2025565532 @default.
• W2025565532 citedByCount "66" @default.
• W2025565532 countsByYear W20255655322014 @default.
• W2025565532 countsByYear W20255655322015 @default.
• W2025565532 countsByYear W20255655322016 @default.
• W2025565532 countsByYear W20255655322017 @default.
• W2025565532 countsByYear W20255655322018 @default.
• W2025565532 countsByYear W20255655322019 @default.
• W2025565532 countsByYear W20255655322020 @default.
• W2025565532 countsByYear W20255655322021 @default.
• W2025565532 countsByYear W20255655322022 @default.
• W2025565532 countsByYear W20255655322023 @default.
• W2025565532 crossrefType "journal-article" @default.
• W2025565532 hasAuthorship W2025565532A5002750621 @default.
• W2025565532 hasAuthorship W2025565532A5023170050 @default.
• W2025565532 hasAuthorship W2025565532A5030623527 @default.
• W2025565532 hasAuthorship W2025565532A5042380073 @default.
• W2025565532 hasAuthorship W2025565532A5043798697 @default.
• W2025565532 hasAuthorship W2025565532A5048094266 @default.
• W2025565532 hasAuthorship W2025565532A5058816305 @default.
• W2025565532 hasAuthorship W2025565532A5059216740 @default.
• W2025565532 hasAuthorship W2025565532A5066141484 @default.
• W2025565532 hasAuthorship W2025565532A5071458554 @default.
• W2025565532 hasAuthorship W2025565532A5076511286 @default.
• W2025565532 hasBestOaLocation W20255655322 @default.
• W2025565532 hasConcept C121608353 @default.
• W2025565532 hasConcept C184235292 @default.
• W2025565532 hasConcept C185592680 @default.
• W2025565532 hasConcept C2994372470 @default.
• W2025565532 hasConcept C502942594 @default.
• W2025565532 hasConcept C54355233 @default.
• W2025565532 hasConcept C55493867 @default.
• W2025565532 hasConcept C57074206 @default.
• W2025565532 hasConcept C70721500 @default.
• W2025565532 hasConcept C74187038 @default.
• W2025565532 hasConcept C81885089 @default.
• W2025565532 hasConcept C86803240 @default.
• W2025565532 hasConcept C96232424 @default.
• W2025565532 hasConceptScore W2025565532C121608353 @default.
• W2025565532 hasConceptScore W2025565532C184235292 @default.
• W2025565532 hasConceptScore W2025565532C185592680 @default.
• W2025565532 hasConceptScore W2025565532C2994372470 @default.
• W2025565532 hasConceptScore W2025565532C502942594 @default.
• W2025565532 hasConceptScore W2025565532C54355233 @default.
• W2025565532 hasConceptScore W2025565532C55493867 @default.
• W2025565532 hasConceptScore W2025565532C57074206 @default.
• W2025565532 hasConceptScore W2025565532C70721500 @default.
• W2025565532 hasConceptScore W2025565532C74187038 @default.
• W2025565532 hasConceptScore W2025565532C81885089 @default.
• W2025565532 hasConceptScore W2025565532C86803240 @default.
• W2025565532 hasConceptScore W2025565532C96232424 @default.
• W2025565532 hasIssue "5" @default.
• W2025565532 hasLocation W20255655321 @default.

• next