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- W2025569306 abstract "The classical visual and β-arrestins belong to a larger family of proteins that likely share structural similarity. Humans have an additional six related proteins sometimes termed the α-arrestins, whose functions are now emerging. Surprisingly, several α-arrestins play prominent roles in the regulation of metabolism and obesity. One α-arrestin, thioredoxin-interacting protein (Txnip), has crucial functions in regulating glucose uptake and glycolytic flux through the mitochondria. Another α-arrestin, Arrdc3, is linked to obesity in men and was recently identified in mice as a regulator of body mass, adiposity, and energy expenditure. Here we discuss recent evidence suggesting potential common themes for all arrestins, including physiological roles for classical arrestins in metabolism and the functions of α-arrestins in receptor signaling and endocytosis." @default.
- W2025569306 created "2016-06-24" @default.
- W2025569306 creator A5020595766 @default.
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- W2025569306 date "2012-05-01" @default.
- W2025569306 modified "2023-09-25" @default.
- W2025569306 title "An expanded family of arrestins regulate metabolism" @default.
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- W2025569306 doi "https://doi.org/10.1016/j.tem.2012.03.003" @default.
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