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- W2025576903 abstract "Diffusion tensor imaging (DTI) and immunohistochemistry were performed in spinal cord injured rats to understand the basis for activation of multiple regions in the brain observed in functional magnetic resonance imaging (fMRI) studies. The measured fractional anisotropy (FA), a scalar measure of diffusion anisotropy, along the region encompassing corticospinal tracts (CST) indicates significant differences between control and injured groups in the 3 to 4 mm area posterior to bregma that correspond to internal capsule and cerebral peduncle. Additionally, DTI-based tractography in injured animals showed increased number of fibers that extend towards the cortex terminating in the regions that were activated in fMRI. Both the internal capsule and cerebral peduncle demonstrated an increase in GFAP-immunoreactivity compared to control animals. GAP-43 expression also indicates plasticity in the internal capsule. These studies suggest that the previously observed multiple regions of activation in spinal cord injury are, at least in part, due to the formation of new fibers." @default.
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- W2025576903 date "2008-07-01" @default.
- W2025576903 modified "2023-09-27" @default.
- W2025576903 title "Brain fiber tract plasticity in experimental spinal cord injury: Diffusion tensor imaging" @default.
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- W2025576903 doi "https://doi.org/10.1016/j.expneurol.2008.03.018" @default.
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